SKU: 3162844118

Kupfertoxikose (CT) - Labrador Retriever

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Description

Kupfertoxikose (CT) - Labrador RetrieverStoffwechselstrungen des Kupfers sind genetische Strungen des Kupferstoffwechsels in der Leber, die durch Mutationen in zwei Genen verursacht werden, die Kupfertransporter kodieren ATP7A und ATP7B. Der ATP7A Transporter ist entscheidend fr den Kupfertransport von Fibroblasten in die Leber und der ATP7B ist entscheidend fr den Kupferexport aus der Leber. Mutationen im ATP7A fhren zu einem defekten ATP7A Transporter, sodass das Kupfer nicht richtig aus

Stoffwechselstörungen des Kupfers sind genetische Störungen des Kupferstoffwechsels in der Leber, die durch Mutationen in zwei Genen verursacht werden, die Kupfertransporter kodieren – ATP7A und ATP7B. Der ATP7A-Transporter ist entscheidend für den Kupfertransport von Fibroblasten in die Leber und der ATP7B ist entscheidend für den Kupferexport aus der Leber. Mutationen im ATP7A führen zu einem defekten ATP7A-Transporter, sodass das Kupfer nicht richtig aus den Fibroblasten exportiert und in die Leber importiert werden kann, was zu einem Kupfermangel in der Leber führt. Dies führt zu Menkes-Krankheit, einer tödlichen neurodegenerativen Erkrankung, die durch zerebrale und zerebelläre Degeneration, Gedeihstörung, grobes Haar und Bindegewebsanomalien gekennzeichnet ist. Währenddessen führen die Mutationen im ATP7B-Gen zu einem defekten ATP7B-Transporter, sodass das Kupfer nicht richtig aus der Leber exportiert werden kann, was zu einer Kupferansammlung in der Leber und sekundär im Gehirn führt. Dies führt zu Morbus Wilson, was bei mittelalten Hunden zu Zirrhose und neuronaler Degeneration führt. Die Mutation im ATP7A-Gen hat eine X-chromosomale Vererbung und die Mutation im ATP7B-Gen hat eine unvollständig dominante Vererbung. Störungen treten bei Labrador Retrievern und Dobermann Pinschern auf. Bei Dobermann Pinschern werden jedoch Mutationen in beiden Genen gefunden, aber nur die Mutation im ATP7B kann zu einer Störung führen, in diesem Fall Morbus Wilson. Bei Labrador Retrievern können Mutationen nur in einem oder in beiden Genen gleichzeitig vorhanden sein. Mutationen in beiden Genen gleichzeitig können zu einer abnorm hohen Kupferansammlung führen, die zu Kupfertoxikose führt, insbesondere bei Hündinnen.

Vererbung: komplex

Mutation: ATP7A und ATP7B Gen

Gentest: Die Methode, die für den Gentest verwendet wird, ist äußerst genau und ermöglicht eine vollständige Unterscheidung zwischen betroffenen Tieren, Trägern und gesunden Hunden. DNA-Tests können in jedem Alter durchgeführt werden.

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SKU: 3162844118

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4.2 ★★★★★
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Michelle Kim
Boise, US
★★★★★ 4
Everything a Teething Puppy Could Need — Well-Thought-Out Kit
Size: X-Small, Color: Teething Bone
The Nylabone New Puppy Starter Kit is a solid all-in-one solution for the first few months of puppy ownership. It comes with multiple chew toys and bones designed specifically for teething puppies, and my little one took to them right away. The variety keeps him engaged, and I appreciate that each item is designed to be gentle on developing teeth while still satisfying his urge to chew. What differentiates this kit from other puppy chew sets on Amazon is the thoughtful selection of textures and shapes. It’s clear these toys are designed to stimulate gums, promote healthy chewing habits, and even support dental care. I also like that everything is non-toxic and durable enough to survive a few enthusiastic chews. The only reason I didn’t give 5 stars is that the kit might be a bit small for larger breeds, or for puppies that are particularly aggressive chewers. But for standard small to medium pups, it’s a fantastic starter kit that keeps both puppy and owner happy. ✅ Bottom line: A reliable, well-designed starter kit for teething puppies which is thoughtful, durable, and engaging. Makes a great gift for new puppy owners or a practical addition to your own puppy’s toy collection.
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Reviewed in the United States on September 26, 2025
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Valarie Amundsen
Lowell, US
★★★★★ 5
Chew
Size: X-Small, Color: Ring Bone
My dog loves this little chewy bone and it’s good for her teeth. That was very cheap on a sale. It’s worth giving it a try highly recommend it.
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Reviewed in the United States on June 11, 2026
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princeton von d
Draper, US
★★★★★ 3
Chicken Flavor Good, But 🔄 Rotation-Resistant✖; Best for Simpler Chewers
Size: X-Small, Color: Ring Bone, Size: X-Small, Color: Ring Bone
🐾 Hi, I’m PVD; plush sophisticate, chew critic, and active curator of rotational toy relevance. This ring bone and I never fully bonded. I sampled it maybe five times in my entire puppyhood before quietly returning it to the bin (with a single judgmental glance). Still, it does have value for the right pup. ⭐ Why I originally wanted to love it: ✔️ XS size works well for very young puppies ✔️ Chicken flavor lasts impressively long ✔️ Freezing offers temporary gum relief ✔️ Durable and safe; no odd odors or shredding 🌀 Why it’s now a respectful 3-star chew in my rotation: ✘ Never became a go-to toy (5 uses max in my life) ✘ Ring shape felt awkward, not natural or chic; hard to grip and maneuver ✘ Texture too tame vs. nubs or detailed chew surfaces ✘ When I was smaller, I much preferred the Nylabone Baby Blue Bone Chew Toy with nubs (my personal classic), and have since matured into nightly Nylabone “Nubz” edible bones This Ring Bone is Best For: • Very young puppies with minimal chew preferences • Dogs who like simple textures and circular shapes • Those just starting enrichment chew play • Freezer treat rotations (briefly) 🚫 Not ideal for: picky pups, advanced chewers, or dogs who analyze toy ergonomics (like myself). 📝 Final Re-Barks: A strong, well-made chew, but lacked the intrigue to make my permanent rotation. Works for basic chew enjoyment; not for pups with elevated taste or toy ambition. — PVD (Chew Strategist, Textural Analyst & Aspire-to-Vine Reviewer 🐶💼)
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Reviewed in the United States on September 17, 2025
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Kaitlynne Lynch
Waukegan, US
★★★★★ 5
Puppy loves it!
Size: X-Large, Color: Teething Bone, Size: X-Large, Color: Teething Bone
My small puppy loves this bone! I originally purchased this for a larger dog, but my small 10 pound puppy loves it more. It’s good quality and a softer material for puppies!
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Reviewed in the United States on May 10, 2026
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Jesse Arner
Omaha, US
★★★★★ 4
A hit, but could be stronger
Size: Medium, Color: Ring Bone, Size: Medium, Color: Ring Bone
Gave this to my 11 week old pittie, and she did significant damage within 15 mins. She left a pile of chewed bits on the couch but thankfully didn't eat them. Definitely don't leave unsupervised. That said, she LOVED it and it seemed to help her teething gums so, I'm still giving it a 4/5 Puppy pics for tax
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Reviewed in the United States on June 3, 2026

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