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Description
human bsep vesicle kit hek293Das Human BSEP Vesicle Kit enthlt Inside out Membranvesikel aus HEK293 Zellen, die transient die Bile Salt Export Pump (BSEP ABCB11) berexprimieren. BSEP ist der primre hepatische Efflux Transporter fr Gallensalze und ein zentrales Zielprotein in der Risikoabschtzung fr medikamenteninduzierte Cholestase (DILI). Das Kit ist konform mit den FDA (2017) und EMA (2013) Leitlinien fr DDI Studien. Hergestellt von Cell4Pharma. Exklusiv im DACH Raum erhltlich
Das Human BSEP Vesicle Kit enthält Inside-out Membranvesikel aus HEK293-Zellen, die transient die Bile Salt Export Pump (BSEP / ABCB11) überexprimieren. BSEP ist der primäre hepatische Efflux-Transporter für Gallensalze und ein zentrales Zielprotein in der Risikoabschätzung für medikamenteninduzierte Cholestase (DILI). Das Kit ist konform mit den FDA (2017)- und EMA (2013) Leitlinien für DDI Studien.
Hergestellt von Cell4Pharma. Exklusiv im DACH-Raum erhältlich über SeamlessBio.
Transporter-Profil
Name: BSEP, Bile Salt Export Pump, ABCB11, ATP-bindende Kassette Unterfamilie B Mitglied 11
Gen: ABCB11
ATP/AMP-Ratio: >10 (garantiert)
Gewebsexpression: Kanalikuläre Plasmamembran der Hepatozyten
Erkrankungen: Erbliche und medikamenteninduzierte Cholestase (DILI)
Bekannte Substrate: Taurocholat, Pravastatin, Taurolithocholyl-3-Sulfat, konjugierte monovalente Gallensalze
In stock: Human, Katze, Hund
Kit-Inhalt (100 Reaktionen)
- Vesikel-Vial (100 Reaktionen), BSEP überexprimierende HEK293-abgeleitete Vesikel
- AMP-ATP-Lösung (100 mM), Cell4Pharma
- Assay-Puffer, Cell4Pharma
Anwendungen
- allensalztransport-Inhibitionsstudien (Cholestase-Risikoabschätzung)
- Drug-Induced Liver Injury (DILI) Screening
- Drug-Drug-Interaction-(DDI)-Studien gemäß FDA/EMA-Leitlinien
- Substratidentifikation für hepatische Efflux-Transporter
- High-Throughput-Screening (Radiolabel-, Fluoreszenz-, LC-MS-Detektion)
Regulatorische Konformität
Die Hemmung von BSEP ist ein etablierter Mechanismus der medikamenteninduzierten cholestatischen Leberschädigung. Die Bewertung der BSEP-Hemmung wird in den FDA (2017)- und EMA (2013)-DDI-Leitlinien als Teil des Transporter-Charakterisierungspakets für neue Molekülentitäten (NMEs) in der klinischen Entwicklung empfohlen.
Technische Spezifikationen
Wirtszelle: HEK293 (humane embryonale Nierenzelle)
Vesikeltyp: Inside-out-Membranvesikel
Format: 100 Reaktionen pro Kit
Detektion: Radiolabel / Fluoreszenz / LC-MS kompatibel
Lagerung: –80 °C
Verwandte Produkte
- Human Control Vesicle Kit (C4PVK009) – empfohlen als Negativkontrolle in BCRP-Transportassays
- Human MRP2 Vesicle Kit (C4PVK002) – for parallel hepatic efflux assessment
- Human BCRP Vesicle Kit (C4PVK006) – for complete efflux transporter panel
- ciPTEC-OAT1 Assay-Ready Cells – für zellbasierte Nephrotoxizitäts- und Transporterstudien
- Human Serum AB Male OTC (SeamlessBio) – zur Supplementierung von ciPTEC-Kulturmedien
Alle Produkte auf Anfrage.
Kontakt: [email protected] | Telefon: +49 851 37932226
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4.2 ★★★★★
Based on 10 reviews
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Product Reviews
★★★★★ 1
Bought a "Used like new" watch. Doesn't keep time
Color: Black/Black/Black/Fast-Wrap
I've had this for a few weeks. Since then, it's lost about 30 seconds. I'm not sure if it's this specific unit that has the issue or the mechanism itself. It's a shame because it's a killer looking watch.
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Reviewed in the United States on May 8, 2026
★★★★★ 5
Another Great Timex !
Color: Brown/Brown/Natural, Color: Brown/Brown/Natural
Great beater watch. Lime on hands glows for 15 mins. Indigo is brite. Legibility is great. Fits small wrist well. Great watch!
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Reviewed in the United States on April 14, 2026
★★★★★ 3
Light, retro watch
Color: Brown/Brown/Natural
This is a light, comfortable and retro-stylish watch. A mixture of plastic, canvas, and faux-leather makes a good match for a college professor's tweed jacket with leather shoulders and elbow patches. It looks and feels cheap but it's actually a pretty good watch.
Mine has a high contrast face making it easy to read. The hands have lume on them but it only glows for a few minutes. There is an indiglo feature when you press the winder so that's great. The day window is tiny and almost unreadable even with reading classes but other than that it is very functional.
You can adjust the time and day independently (so you don't have to wind through 100+ hours to get the right day displayed). The winder setting to select between time and day adjust is very finicky. Fortunately you only need to adjust the day 5 times a year.
The weakest part is the build quality. I'm not expecting Rolex, but the case corrodes really badly and the strap is short and the stitching failed so it fell off my wrist in about 6 months. I replaced the strap with a better one but the case corroded so badly I tossed it within a year.
Other than looking cheap, poor build quality, and being thicker than I would like, I think this is a good watch.
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Reviewed in the United States on June 17, 2025
★★★★★ 5
A nice, comfortable watch.
Color: Black/ Green
A nice inexpensive everyday watch. It is accurate, a nice size for my wrists. You barely feel it as it is so light. it has a nice clear face Andy only gripe is that I wished it had slightly better loom. Other than that it is a great watch for the money and this is coming from someone with 30+ watches in my collection in all price ranges. It has earned its way into my regular watch rotation.
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Reviewed in the United States on August 14, 2025
★★★★★ 4
Good Watch for use in water.
Color: Black/ Green
Here's the deal. It's an excellent plastic watch. If you don't abuse it, it should last years. The advantage of metal bodies and crystal faces, is that they're lot more resistant to scratches compared to plastic, BUT they weigh a lot more than plastic watches. I love the size of this watch while at the same time, it surprisingly light on the wrist. Therefore it doesn't move all around like a heavy steel watch. I hardly know Im wearing this plastic watch. Also, I went snorkling offshore for a week with this watch, no leaks, no problems. It will stand up to water fine. So, if you don't abuse it, its a pleasure to wear, lightweight, waterproof, doesnt slip around, looks good. I imagine the battery should last 3-5 yrs like my last plastic quartz watch. For the price, its a very good watch.
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Reviewed in the United States on April 11, 2025
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