SKU: 8658105379

Dilatative Kardiomyopathie (DCM3, DCM4) - Dobermann Europäischer Herkunft

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Description

Dilatative Kardiomyopathie (DCM3, DCM4) - Dobermann Europäischer HerkunftDilated cardiomyopathy (DCM) ist eine komplexe, lebensbedrohliche Erkrankung des schwachen und dnnen Herzens. Sie ist gekennzeichnet durch eine linksventrikulre Dilatation und systolische Dysfunktion mit anschlieender Entwicklung von sowohl atrialen als auch ventrikulren Tachyarrhythmien, die zur Entwicklung einer kongestiven Herzinsuffizienz und pltzlichem Herztod aufgrund der verringerten Fhigkeit, Blut zu pumpen, fhren knnen. Die klinischen

Dilated cardiomyopathy (DCM) ist eine komplexe, lebensbedrohliche Erkrankung des schwachen und dünnen Herzens. Sie ist gekennzeichnet durch eine linksventrikuläre Dilatation und systolische Dysfunktion mit anschließender Entwicklung von sowohl atrialen als auch ventrikulären Tachyarrhythmien, die zur Entwicklung einer kongestiven Herzinsuffizienz und plötzlichem Herztod aufgrund der verringerten Fähigkeit, Blut zu pumpen, führen können. Die klinischen Anzeichen umfassen Belastungsintoleranz, anhaltenden Husten, Schwäche, Gewichtsverlust, Atembeschwerden, Ohnmacht und Schwellungen des Bauches. DCM ist eine ernsthafte Erkrankung und obwohl es keine Heilung gibt, können die betroffenen Hunde Therapien erhalten, um Arrhythmien zu kontrollieren, die Herzfunktion zu verbessern und die kongestive Herzinsuffizienz zu managen, um das Fortschreiten der Erkrankung zu steuern und die Lebensqualität zu optimieren.

DCM ist mit 4 verschiedenen Risikovarianten assoziiert. Die Mutationen DCM1 und DCM2 werden beide dominant vererbt und sind hauptsächlich in den USA verbreitet, während die beiden folgenden Mutationen, DCM3 und DCM4, hauptsächlich in Europa vorkommen, wobei DCM3 einem dominanten Vererbungsmuster folgt und DCM4 einem rezessiven Vererbungsmuster. Die Ergebnisse der genetischen Tests zeigten, dass DCM1 und DCM2 assoziierte Bindungsmarker für DCM bei US-Dobermännern sind und dass DCM3 und DCM4 hochgradig assoziierte Bindungsmarker für DCM bei europäischen Dobermännern sind, während DCM1/DCM2 gezeigt haben, dass sie keine Assoziation mit Risiko bei europäischen Dobermännern haben.

DCM ist eine Erkrankung multifaktorieller Natur, was bedeutet, dass es keinen genauen genetischen Risikofaktor gibt und auch andere genetische oder umweltbedingte Faktoren die Entwicklung und das Fortschreiten der Krankheit beeinflussen können. Es gibt auch keinen offensichtlichen Unterschied in der klinischen Schwere zwischen Hunden, die von einer der Mutationen betroffen sind, wobei alle betroffenen Hunde die Krankheit bis zum Alter von 6 Jahren entwickeln. Es besteht jedoch ein potenziell höheres Risiko, DCM zu entwickeln, wenn ein Hund Träger oder betroffen von zwei oder mehr Kombinationen von Risikovarianten ist.

Für US-Dobermänner: Das Risiko, dass Hunde eine DCM entwickeln, basierend auf der Vererbung beider Varianten DCM1 und DCM2, wird als höher angesehen als bei denen, die von keiner Risikovariante betroffen sind. Allerdings werden nicht alle Hunde mit den Varianten DCM entwickeln, sodass die Varianten eine unvollständige Penetranz aufweisen.

Für die europäischen Dobermänner: Risiko, eine DCM basierend auf der Vererbung der Risikovarianten DCM3 und DCM4 zu entwickeln (für ein besseres Verständnis siehe die Tabelle unten). Beachten Sie, dass DCM4 einen stärkeren Einfluss auf das Risiko hat im Vergleich zu DCM3.

Genotyp / Risiko

DCM4 klar

DCM4 Träger

DCM4 betroffen

DCM3 klar

geringes Risiko

geringes Risiko

hohes Risiko

DCM3 Träger

mittleres Risiko

mittleres Risiko

hohes Risiko

DCM3 betroffen

hohes Risiko

hohes Risiko

höchstes Risiko

 

Für Züchter: Angesichts der begrenzten Anzahl klarer Hunde für DCM-Varianten sollten Züchter sich darauf konzentrieren, die Häufigkeit der Hunde mit dem höchsten Risiko über mehrere Generationen schrittweise zu reduzieren, um die guten genetischen Eigenschaften sicher an zukünftige Würfe weiterzugeben und das Risiko der Entwicklung einer DCM zu eliminieren. Diese Vorgehensweise birgt jedoch das Risiko, bestimmte Zuchtlinien übermäßig zu nutzen, was zu Engpässen in der Population und einer Verringerung der genetischen Vielfalt innerhalb der Rasse führen kann.

Vererbung: komplex

Mutation: PDK4, TTN, SNP auf Chromosom 5, RNF207

Gentest: Die verwendete Methode für den Test ist äußerst genau und ermöglicht eine vollständige Differenzierung zwischen betroffenen Tieren, Trägern und gesunden Hunden. Der Test kann in jedem Alter durchgeführt werden.

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SKU: 8658105379

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4.7 ★★★★★
Based on 27 reviews
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A
Verified Purchase
Amazon Customer
Belleville, US
★★★★★ 5
Easy Set Up and Great Sound Distribution
Style: AVR-X3800H
I replaced an old Onkyo 535 with this Denon. It was a significant upgrade. There is zero noise, the Bluetooth is easy to use and provides excellent sound, and the HDMI circuitry is outstanding. The eARC capability is compatible with 2.1 HDMI, and it works seamlessly. Of note, I really like the way it provides the best sound configuration automatically for each source, and I don't have to switch around to find the best sound option. For example, if the source is compatible with Atmos, it provides Atmos. If it's only compatible with Dolby surround, it switches to that. Finally, the distribution of sound is superb. I have a 7.1 speaker configuration of mostly mid-level speakers, and the Denon uses them to their fullest. Rear sounds come clearly from the rear...same with each side, etc. And most of all, I don't have to tweak the system to get that. I just used the provided microphone and ran the set up (which was really easy), and I have really great sound. This unit is a good value.
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Reviewed in the United States on January 28, 2026
R
Verified Purchase
Reviewer JR
Dallas, US
★★★★★ 4
Expensive, but nice
Style: AVR-X4800H
I previously owned a Denon AVR-2808ci since 2008. That model's remote control didn't work well, and all controls were unnecessarily convoluted, so I was hesitant to buy another Denon. The thing that made me give them another chance is that the sound quality was nice, and I was hoping their engineers learned from their mistakes. I'm glad I gave them the chance. This new model, the AVR-X4800H, also has excellent sound quality; however, unlike the old one I had, the controls on both the receiver itself, and especially on the remote control, are significantly improved. The controls are intuitive, and everything works perfectly. That alone made me happy with the purchase; however, the ability to run 4k @ 120 hz for video gaming, and with extra HDMI ports they have here, all added to that value quite a bit. Then, in addition to that, the old model I had ran super hot. In fact, so hot, from just basic usage, it fried itself three different times in the span of a couple weeks (during the winter time), and it kept being repaired under warranty, until they replaced the top grate with one that allows more ventilation. However, this new model doesn't appear to suffer from that same issue. It gets pretty warm, but nowhere near what the old one did -- and I'm using the same Bose Surround Sound system with the new one. That said, as a precaution, I went ahead and ordered an AC Infinity AirCom to put on top of it, to assist with cooling/ventilation, which has worked wonderfully as well. No the tempts on this Denon AVR have never gone above 87 deg, even on a warm room on the third floor during the late spring / summer time. The other hesitancy I had was the price tag. I only purchased it because it was on a "25% discount", from $2500 down to around $1850. Granted, it was similar when I purchased the other one 15 years ago, but it's just an awful lot of money, in my humble opinion. I would say it was borderline on whether I would buy it for this amount, and if it went up at all, I wouldn't have purchased it. I may not purchase it again for this price, especially if I have one already that is working well -- it was only the wonky one that I already owned, that I just wanted to get rid of, that put more pressure to give them one more chance. With a working device, I probably wouldn't pay these prices again. But, if it were a few hundred dollars cheaper, then I probably would buy it again. Hopefully this helps someone. It's a great device, just a bit expensive. And, if you get it, I would still recommend getting a top cooling fan for it.
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Reviewed in the United States on June 13, 2024
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Verified Purchase
B. Husher
Charlottesville, US
★★★★★ 5
Solid Next-Generation AVR.
Style: AVR-X2800H
I bought this for my 2.1 system used for TV (4K with 120 Hz), movies, video games (4K with 120 Hz), turntable, and digital audio. I have previously used Denon, Marantz, and NAD AVRs. I was using an old NAD without HDMI, and I really wanted everything to synch up. I tried out a stereo receiver since I am only running a 2.1, but I didn't mesh for me. It was fine, but I felt it was lacking especially around multi-channel audio and the lack of an LFE output for the sub. The 2800H was very intuitive and easy to set up right out of the box. Hooked up to a TV, it runs through everything step-by-step. After the initial setup, I downloaded and ran a firmware update. When I finally got to use my ears, the sound was already superior to what I had from the mid-2000s 60-watt-per-channel NAD AVR with an external Bluetooth/DAC and PCM cable from the TV AND the brand-new, 2023 model HDMI-equipped stereo receiver (that cost me more than the 2800H). After running Audyssey, the sound only got better. Then, I set up my 2 front speakers on a bi-amp setting, utilizing two of my unused channels to drive my woofer and tweeter with discrete power sources. The eARC and settings makes turning on my TV, PS5, and AVR easier and quicker. I enjoy the fact that I can use any remote to fix the volume so there is always a remote close when we need a quick mute or change in the volume. I find the HEOS app to be a little clunky, but I am loving it anyway. I can run high-definition audio through streaming, which is a huge improvement from using Apple Airplay 2 or Bluetooth. It also lets me talk on the phone, send and receive messages, etc. without interrupting the music. Right now, I am still tweaking my settings, but I can definitely say that the sound is really good. Have I heard better? Sure. This isn't an 11-channel receiver with Dirac, a 200 watt-per-channel, high-end "audiophile"-grade component, or a tube amp. It is best at multi-channel audio and does really well for music, especially with a good set of speakers and quality sub with parametric EQ. My speakers have are low sensitivity (84dB), and the 2800H puts out enough grunt to listen give nuance and life to music in listening position, to bump the music to listen in my kitchen two rooms over, or watch at theater-level volume in my medium-sized living room with 8-foot ceilings. This thing is getting daily use, and it is more than enough to get the job done in style. For what I need, the 2800H is spot on.
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Reviewed in the United States on November 9, 2023
S
Verified Purchase
superx1
Chelsea, US
★★★★★ 5
High-Quality Wire That’s Worth Every Foot
Size: 14/2 AWG-200 FT, Color: White
The GEARit 14 Gauge Speaker Wire (200 ft, CL2 rated) has been a great addition to my home audio setup. The 14 gauge thickness feels solid and gives me confidence that I’m getting good signal transfer without unnecessary loss, even over long runs. The CL2 rating is a big plus — it’s reassuring to know this cable is safe and approved for in-wall installation if I ever decide to run speakers through the walls rather than on the surface. What I like most: Flexible yet strong — easy to pull through studs and around corners Clear polarity markings — no guesswork when wiring speakers Smooth insulation — doesn’t snag or tangle while measuring and cutting Good value for 200 ft — plenty to cover multiple rooms or channels Whether you’re doing a DIY install or upgrading your audio system, this speaker wire delivers solid performance and peace of mind. Highly recommended!
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Reviewed in the United States on February 21, 2026
Y
Verified Purchase
Yusuf Burns
Draper, US
★★★★★ 5
Quality wires
Size: 14/2 AWG-200 FT, Color: White
My speakers 🔊 are working much better and the sound is a lot better
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Reviewed in the United States on May 4, 2026

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