Shipping Estimate
USA
- USA
- CAN
- USA
- CAN
Ships within 48 hours · Estimated delivery Jul 11 - Jul 16
Promo Codes Available:
For Your Every Summer RSVP, with Code: SUMMER15
Description
APC Mouse Anti-Mouse CD64 Antibody (S-R614)Product Specification Host Mouse Antigen CD64 Synonyms High affinity immunoglobulin gamma Fc receptor I; IgG Fc receptor I; Fc gamma RI (FcRI); Fcg1; Fcgr1 Location Cell membrane Accession P26151 Clone Number S R614 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Ms Positive Sample RAW 264. 7 Purification Protein G Concentration 0. 2 mg ml Conjugation APC Physical Appearance Liquid Storage Buffer PBS, 1% BSA, 0. 3% Proclin 300
Product Specification
| Host | Mouse |
| Antigen | CD64 |
| Synonyms | High affinity immunoglobulin gamma Fc receptor I; IgG Fc receptor I; Fc-gamma RI (FcRI); Fcg1; Fcgr1 |
| Location | Cell membrane |
| Accession | P26151 |
| Clone Number | S-R614 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | RAW 264.7 |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | APC |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1.25μl per million cells in 100μl volume | Ms |
Background
CD64, also known as Fc-gamma receptor I (FcγRI), is a 72-kDa type I transmembrane glycoprotein encoded by the FCGR1A gene on chromosome 1. It belongs to the immunoglobulin superfamily and is composed of three extracellular Ig-like C2-type domains, a single transmembrane region, and a short cytoplasmic tail that associates with the Fc receptor γ-chain containing an ITAM motif to mediate intracellular signaling. CD64 is constitutively expressed on monocytes, macrophages, and dendritic cells, and can be rapidly up-regulated on neutrophils by pro-inflammatory stimuli such as IFN-γ, LPS, or G-CSF. It functions as a high-affinity receptor for the Fc portion of IgG, particularly IgG1 and IgG3, enabling key immune processes including phagocytosis, antigen presentation, antibody-dependent cellular cytotoxicity (ADCC), and the release of reactive oxygen species and cytokines. Its expression is tightly linked to innate immune activation, making CD64 a sensitive biomarker for bacterial infections and inflammatory disorders such as sepsis and rheumatoid arthritis.
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy