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Description
KCNB1 Recombinant Rabbit mAb (S-2527-21)Product Specification Host Rabbit Antigen KCNB1 Synonyms Potassium voltage gated channel subfamily B member 1; Delayed rectifier potassium channel 1 (DRK1; h DRK1); Voltage gated potassium channel subunit Kv2. 1 Immunogen Synthetic Peptide Location Cell membrane Accession Q14721 Clone Number S 2527 21 Antibody Type Recombinant mAb Isotype IgG Application IHC P, ICC Reactivity Hu, Ms, Rt Positive Sample SH SY5Y Purification Protein A Concentration 0. 5
Product Specification
| Host | Rabbit |
| Antigen | KCNB1 |
| Synonyms | Potassium voltage-gated channel subfamily B member 1; Delayed rectifier potassium channel 1 (DRK1; h-DRK1); Voltage-gated potassium channel subunit Kv2.1 |
| Immunogen | Synthetic Peptide |
| Location | Cell membrane |
| Accession | Q14721 |
| Clone Number | S-2527-21 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | IHC-P, ICC |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | SH-SY5Y |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| IHC-P | 1:1000 | Hu, Ms, Rt |
| ICC | 1:50 | Hu |
Background
KCNB1, also known as Kv2.1, is a 96-kDa, 858-amino-acid voltage-gated delayed-rectifier potassium channel α-subunit encoded on chromosome 20q13.3 that forms homo- or heterotetrameric pores (with silent α-subunits like KCNG, KCNV, KCNS families and regulatory β-subunits such as KCNE1-3) responsible for mediating outward K+ currents essential for repolarization of excitable membranes during high-frequency firing . The channel is enriched in somatodendritic domains of cortical and hippocampal neurons, pancreatic β-cells, heart, lungs and retina, and its gating, trafficking and clustering are dynamically regulated by phosphorylation/dephosphorylation of its cytoplasmic N- and C-termini in response to neuronal activity, transmitters, Ca2+/calcineurin signalling and oxidative stress, thereby controlling neuronal excitability, insulin secretion and apoptosis . Pathogenic KCNB1 variants produce epileptic encephalopathy, developmental delay and motor impairment by disrupting ion selectivity or inducing gain-of-function cation conductance.
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