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Description
S-RMab® Cadherin 17 Recombinant Rabbit mAb (SDT-736-23)Product Specification Host Rabbit Antigen Cadherin 17 Synonyms LI cadherin, Intestinal peptide associated transporter HPT 1, Liver intestine cadherin, CDH17 Immunogen Synthetic Peptide Location Cell membrane Accession Q12864 Clone Number SDT 736 23 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu, Ms, Rt Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS,
Product Specification
| Host | Rabbit |
| Antigen | Cadherin 17 |
| Synonyms | LI cadherin, Intestinal peptide-associated transporter HPT-1, Liver-intestine cadherin, CDH17 |
| Immunogen | Synthetic Peptide |
| Location | Cell membrane |
| Accession | Q12864 |
| Clone Number | SDT-736-23 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | |
| IHC-P | 1:500-1:2000 |
Background
This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. The encoded protein is cadherin-like, consisting of an extracellular region, containing 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine. In normal tissues, LI cadherin antibodies are labeled on epithelial cells of the gastrointestinal and pancreatic tracts, but not on epithelial cells of the kidneys, liver, and other tissues. In tumors, it is expressed in digestive system adenocarcinoma, including cancer. It is a sensitive biomarker for distinguishing gastrointestinal metaplasia from well differentiated adenocarcinoma.
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