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Description
SDHB Recombinant Rabbit mAb (SDT-1162-2)Product Specification Host Rabbit Antigen SDHB Synonyms Mitochondrial succinate dehydrogenase [ubiquinone] iron sulfur subunit, Iron sulfur subunit of complex II (Ip) Immunogen Synthetic Peptide Accession P21912 Clone Number SDT 1162 2 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC, ICFCM, IF Reactivity Hu, Ms, Rt Predicted Reactivity Xe, Pg, Bv Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical
Product Specification
| Host | Rabbit |
| Antigen | SDHB |
| Synonyms | Mitochondrial succinate dehydrogenase [ubiquinone] iron-sulfur subunit, Iron-sulfur subunit of complex II (Ip) |
| Immunogen | Synthetic Peptide |
| Accession | P21912 |
| Clone Number | SDT-1162-2 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC, ICFCM, IF |
| Reactivity | Hu, Ms, Rt |
| Predicted Reactivity | Xe, Pg, Bv |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | |
| IHC-P | 1:250-1:500 | |
| ICC | 1:500 | |
| ICFCM | 1:500 | |
| IF | 1:200 |
Background
Succinate dehydrogenase B (SDHB) protein is an integral part of the complex II oxidation/reduction pathway. Its function is to transfer electrons from succinate to coenzyme Q.SDHB can be used to differentiate between type 1 (SDHB +) and type 2 (SDHB -) gastrointestinal stromal tumors (GIST).SDHB immunohistochemistry has emerged as a reliable method for diagnosing and screening of SDH-deficient tumors, including SDH-deficient pheochromocytoma/paraganglioma, SDH-deficient GIST, and SDH-deficient renal cell carcinoma.
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