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Description
GABARAP Recombinant Rabbit mAb (S-2372-47)Product Specification Host Rabbit Antigen GABARAP Synonyms Gamma aminobutyric acid receptor associated protein; GABA(A) receptor associated protein; MM46; FLC3B Immunogen Synthetic Peptide Location Cytoplasm, Cytoskeleton Accession O95166 Clone Number S 2372 47 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu, Ms, Rt Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage
Product Specification
| Host | Rabbit |
| Antigen | GABARAP |
| Synonyms | Gamma-aminobutyric acid receptor-associated protein; GABA(A) receptor-associated protein; MM46; FLC3B |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Cytoskeleton |
| Accession | O95166 |
| Clone Number | S-2372-47 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
| IHC-P | 1:1000 | Hu, Ms, Rt |
Background
GABARAP (GABA type A receptor-associated protein) is a 14-kDa cytosolic mammalian ATG8-family protein that, upon activation by ATG7 and ATG3, covalently conjugates to phosphatidylethanolamine on forming autophagosomes, thereby acting as a pivotal scaffold for recruitment and tethering of autophagy receptors such as LC3-interacting region (LIR)-containing cargo adaptors, as well as for ULK1 complex and PI3-kinase complex I assembly; beyond autophagy, it participates in intracellular trafficking, receptor stabilization, cytoskeletal reorganization, and innate immunity by modulating GABAA receptor clustering at synapses, tethering ER to the Golgi via golgin-160, and interacting with NDP52/TBK1 to restrict cytosolic bacteria, and its dysregulation is implicated in neurodegeneration, cancer, and infectious diseases.
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Exchange/Return Notes
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