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Description
Alexa Fluor® 647 Mouse Anti-Human IgE Antibody (S-2853)Product Specification Host Mouse Antigen IgE Synonyms Immunoglobulin heavy constant epsilon; Ig epsilon chain C region; Ig epsilon chain C region ND; IGHE Location Secreted, Cell membrane Accession P01854 Clone Number S 2853 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Positive Sample Human PBMC Purification Protein G Concentration 0. 2 mg ml Conjugation Alexa Fluor 647 Physical Appearance Liquid Storage Buffer PBS, 1% BSA, 0.
Product Specification
| Host | Mouse |
| Antigen | IgE |
| Synonyms | Immunoglobulin heavy constant epsilon; Ig epsilon chain C region; Ig epsilon chain C region ND; IGHE |
| Location | Secreted, Cell membrane |
| Accession | P01854 |
| Clone Number | S-2853 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | Human PBMC |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Alexa Fluor® 647 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
IgE is an antibody isotype that, despite being the least abundant in serum, sits at the epicenter of type I hypersensitivity and anti-parasite immunity; generated by plasma cells in mucosal tissues, it binds with picomolar affinity to the tetrameric FcεRI on mast cells and basophils, priming them for rapid degranulation upon subsequent allergen encounter, thereby unleashing histamine, leukotrienes and cytokines that produce the clinical spectrum from urticaria to anaphylaxis, while also orchestrating eosinophil and macrophage responses against helminths; its half-life in plasma is brief (~2 days), yet it can remain cell-bound for weeks, and its levels are tightly regulated by IL-4, IL-13 and CD40L-mediated class-switching.
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