SKU: 30341770963

ATP7A Recombinant Rabbit mAb (S-2289-106)

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Description

ATP7A Recombinant Rabbit mAb (S-2289-106)Product Specification Host Rabbit Antigen ATP7A Synonyms Copper transporting ATPase 1; Copper pump 1; Menkes disease associated protein; MC1; MNK Immunogen Synthetic Peptide Location Cell membrane Accession Q04656 Clone Number S 2289 106 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu, Ms, Rt Positive Sample A549, HeLa, SH SY5Y, mouse lung, C6 Predicted Reactivity Hm Purification Protein A Concentration 0. 5 mg ml

Product Specification


Host Rabbit
Antigen ATP7A
Synonyms Copper-transporting ATPase 1; Copper pump 1; Menkes disease-associated protein; MC1; MNK
Immunogen Synthetic Peptide
Location Cell membrane
Accession Q04656
Clone Number S-2289-106
Antibody Type Recombinant mAb
Isotype IgG
Application WB, IHC-P
Reactivity Hu, Ms, Rt
Positive Sample A549, HeLa, SH-SY5Y, mouse lung, C6
Predicted Reactivity Hm
Purification Protein A
Concentration 0.5 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


application dilution species
WB 1:1000 Hu, Ms, Rt
IHC-P 1:200 Hu, Ms, Rt

Background

ATP7A (Menkes ATPase) is a copper-transporting P-type ATPase that uses ATP hydrolysis to actively pump Cu(I) across membranes, thereby maintaining cellular copper homeostasis: under normal or low copper conditions it resides in the trans-Golgi network (TGN) and delivers copper to cuproenzymes (e.g., peptidyl-α-monooxygenase, tyrosinase, lysyl oxidase), while under high copper it traffics to the plasma membrane to efflux excess copper; the 1,500-amino-acid protein contains eight transmembrane segments forming a copper channel, an ATP-binding domain, and six N-terminal cytosolic Cu(I)-binding GMTCXXC motifs, and mutations in ATP7A cause the X-linked disorder Menkes disease, characterized by systemic copper deficiency, neurodegeneration, and early death.

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SKU: 30341770963

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4.5 ★★★★★
Based on 9 reviews
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4bonbon
Birmingham, US
★★★★★ 1
Tip will not stay saturated with color
Color: Honey Brown, Size: 1 Count (Pack of 1)
This is a pen with a nice felt tip. First time I used it, it glided on nicely. Second time used about it a week later, tip was dry and no matter how I tried, it would not saturate and provided no color. I even tried storing it with the tip facing down to make the color flood to the tip, but even after several days of standing it up that way, tip was still dry. What a waste of money. I just ordered their Easy Brow and Fill Tool, which is a stick of color that winds in and out and so far like it very much. Would recommend that and not this ink pen.
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Reviewed in the United States on November 30, 2022
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Lisa Gagliardi
Cuba, US
★★★★★ 5
Always Perfect!
Color: Rich Brown, Size: 1 Count (Pack of 1)
The best brow liner I have ever used. My eyebrows have thinned over the years because of a thyroid condition and I have been drawing them on since I had was in my thirties. I believe it really retains my youth and the fact that this is a liquid helps me keep the hairs in place that I already have up there. I do not go anywhere without my eyebrow liner. Add this to your makeup kit! You will thank me.
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Reviewed in the United States on January 1, 2026
T
Verified Purchase
Tracy
Birmingham, US
★★★★★ 5
Easy To Use
Color: Soft Brown, Size: 1 Count (Pack of 1)
Easy to use. Looks natural. Great product. I definitely recommend it.
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Reviewed in the United States on December 28, 2025
K
Verified Purchase
Kathryn Roberts
Whiting, US
★★★★★ 5
Great Brow Pen
Color: Dark Brown, Color: Dark Brown
I love this brow pen; it’s my favorite brow product I’ve ever used. If you aren’t already here because of Katie Jane Hughes on Instagram, I recommend searching her (@katiejanehughes) and she has an instastory highlight about how she uses this pen. I find it’s extremely important to store these pens upside down to allow the “ink” to travel down to the brush, and also to keep the brush pointed down as you use feathering strokes to paint the shape and hairs you want. The faster you work, the better; some people say the pen dries out, though I find I have plenty of time for both brows, especially if I’m using more than one color. You don’t need to use a primer in advance of using these pens (some peoples he trouble if they DO use primer; something about the slippiness makes it difficult for the pen to stick. I’ve never had that issue myself but if you’re struggling try without primer). I also tend to use a brow gel on top of this, but only to wrangle my brow hairs into one direction. You certainly don’t need to. I’ve attached some swatches, since I had a really hard time finding any online. The main difference between “soft black” and “dark brown” is that the dark brown has a warm undertone and is much more opaque than soft black in my opinion. The idea is to use short, light strokes to apply this, so nothing will be too strong unless you want it to be. I tend to go in with soft black first to get the shape I want at the arch and to do some filling in, then I use medium brown on the inside of my brows and also to fill in, and then I use dark brown last just where I need some extra coverage. I certainly don’t recommend being this extra; I bought the colors to see what they looked like and found that I like the dimension of using multiples and also that it helps ensure my pens don’t dry out at an inopportune time.
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Reviewed in the United States on January 16, 2019
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Verified Purchase
Ren
Phoenix, US
★★★★★ 5
my Holy Grail Brow product thank you Katie Jane Hughes
Color: Medium Brown
This is my 3rd or 4th? re-order. I don't know what I will do if it gets discontinued for any reason:( I have very sparse , light brows. This is the only thing in the world that has ever let me make realistic brow hairs, with a small learning curve that don't look drawn on, or fade during the day. The pen will dry out if not left stored upside down. It lasts me at least a few months. I'm always ordering another one before it runs out just so that I'll have a back up. Thank you allure! Glossier has a version of this, but it's less product for more money and the tip isn't a thin as this one. I have even ordered this for friends, it's that good.
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Reviewed in the United States on February 6, 2020

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