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Description
S-RMab® PU.1 Recombinant Rabbit mAb,PBS Only (SDT-R236)Product Specification Host Rabbit Synonyms Transcription factor PU. 1, 31 kDa transforming protein, SPI1 Location Nucleus Accession P17947 Clone Number SDT R236 Antibody Type Recombinant mAb Isotype IgG Application IHC P, ICC, ICFCM Reactivity Hu Purification Protein A Concentration 1 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS Stability & Storage 12 months from date of receipt reconstitution, 4 C as supplied Dilution
Product Specification
| Host | Rabbit |
| Synonyms | Transcription factor PU.1, 31 kDa-transforming protein, SPI1 |
| Location | Nucleus |
| Accession | P17947 |
| Clone Number | SDT-R236 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | IHC-P, ICC, ICFCM |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS |
| Stability & Storage | 12 months from date of receipt / reconstitution, 4 °C as supplied |
Dilution
| application | dilution | species |
| IHC-P | 1:500 | |
| ICC | 1:500 | |
| ICFCM | 1:500 |
Background
Transcription factor PU.1 is a protein that in humans is encoded by the SPI1 gene. The PU.1 transcription factor is essential for hematopoiesis and cell fate decisions. PU.1 can physically interact with a variety of regulatory factors like TFIID, GATA-2, GATA-1 and c-Jun. The protein-protein interactions between these factors can regulate PU.1-dependent cell fate decisions. PU.1 can modulate the expression of 3000 genes in hematopoietic cells including cytokines. It is expressed in monocytes, granulocytes, B and NK cells but is absent in T cells, reticulocytes and megakaryocytes. Its transcription is regulated by various mechanisms.
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