SKU: 34317934011

B7-1/CD80 His Tag Protein, Human

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Description

B7-1/CD80 His Tag Protein, HumanProduct Specification Species Human Accession P33681 1 Amino Acid Sequence Val35 Asn242, with C terminal 10*His VIHVTKEVKEVATLSCGHNVSVEELAQTRIYWQKEKKMVLTMMSGDMNIWPEYKNRTIFDITNNLSIVILALRPSDEGTYECVVLKYEKDAFKREHLAEVTLSVKADFPTPSISDFEIPTSNIRRIICSTSGGFPEPHLSWLENGEELNAINTTVSQDPETELYAVSSKLDFNMTTNHSFMCLIKYGHLRVNQTFNWNTTKQEHFPDNGGGSHHHHHHHHHH Expression System HEK293 Molecular Weight 43 55kDa (Reducing) Purity 95% by SDS PAGE Endotoxin <0. 1EU g Conjugation

Product Specification


Species Human
Accession P33681-1
Amino Acid Sequence Val35-Asn242, with C-terminal 10*His VIHVTKEVKEVATLSCGHNVSVEELAQTRIYWQKEKKMVLTMMSGDMNIWPEYKNRTIFDITNNLSIVILALRPSDEGTYECVVLKYEKDAFKREHLAEVTLSVKADFPTPSISDFEIPTSNIRRIICSTSGGFPEPHLSWLENGEELNAINTTVSQDPETELYAVSSKLDFNMTTNHSFMCLIKYGHLRVNQTFNWNTTKQEHFPDNGGGSHHHHHHHHHH
Expression System HEK293
Molecular Weight 43-55kDa (Reducing)
Purity

>95% by SDS-PAGE

Endotoxin <0.1EU/μg
Conjugation Unconjugated
Tag His Tag
Physical Appearance Lyophilized Powder
Storage Buffer PBS, pH7.4
Reconstitution Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.

Background

As the first identified B7 family member, CD80 is widely expressed in a broad spectrum of tissues, even on some malignant tumor cells, thereby suggesting the potential mechanism of immune evasion of tumor cells.CD80 is recognized as one of the most potent costimulatory molecules by which immune cells limit malignant growth. It is upregulated upon cell stress and it is critical for efficacious immune surveillance during carcinogenesis. Low surface expression of CD80 was reported as an immune escape mechanism of colon carcinoma; on the other hand, its expression resulted enhanced in high-frequency microsatellite instability (MSI) colorectal cancers, a CRC subtype which is highly immunogenic and associated with a better prognosis. Both in vivo and in vitro studies showed that the upregulation of CD80 on tumor cell surface successfully activates antitumor immune responses, while its expression is frequently lost during tumor progression probably due to selective pressure by the immune system. Thus, to develop effective approaches for cancer immunotherapy, strategies for enhancing CD80 expression in tumors are urgently required.

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SKU: 34317934011

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4.1 ★★★★★
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L
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lorraine williams
Whiting, US
★★★★★ 5
Best toy around
Color: Hare - Large
If you have the type of dog that can chew anything up but a bowling ball this is the toy for you my dog has been chewing on it and can't even tear it she loves it she won't let go of it and we're working on 45 minutes this toy is great and I'm going to buy other ones thank you
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Reviewed in the United States on June 12, 2026
P
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Pocadot
Cuba, US
★★★★★ 5
Best toys!
Color: Monsieur Acorn - Large
BEST TOYS!!! My dogs LOVE THESE!!! The bonus toy inside is SOOO FUN!! Last ms them a long time.
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Reviewed in the United States on April 25, 2026
B
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Becca Q.
Dallas, US
★★★★★ 4
Excellent, But Not Strong Enough
Color: Monsieur Acorn - Large
This has become the most engaged my dog has ever been with a toy. He chewed these acorns for an hour and a half STRAIGHT. Sadly, he was able to shred both acorns by this time. For dogs with a normal chewing and shredding amount, this toy would be perfect. However, for a super chewer like our dog (Lab/Malamute), it seems like we're going to need something stronger...
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Reviewed in the United States on December 6, 2025
A
Verified Purchase
Alyse_Luurtsema
Grantham, US
★★★★★ 5
A favorite for my small destroyers
Color: Monsieur Acorn - Large, Color: Monsieur Acorn - Large
My small destroyer dogs LOVE these toys and are always surprised to find another toy after the first and second violent de-stuffing. Definitely a supervision toy for safety, but my terriers love doing their thing when these come out and they last much longer than I had anticipated. Color, design and value all as described, however I literally do not remember if it did squeak because the squeaker would be the first thing gone
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Reviewed in the United States on March 25, 2026
C
Verified Purchase
Catherine Burns
Lexington, US
★★★★★ 1
Doesn’t hold up at all.
Color: Hare - Large, Color: Hare - Large
Received this today, and it lasted less than an hour before it had to be taken away to prevent it being eaten.
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Reviewed in the United States on May 11, 2026

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