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Description
TPO Recombinant Rabbit mAb (SDT-420-57)Product Specification Host Rabbit Synonyms Thyroid peroxidase Immunogen Synthetic Peptide Location Membrane Accession P07202 Clone Number SDT 420 57 Antibody Type Recombinant mAb Isotype IgG Application IHC P Reactivity Hu Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03% Proclin 300 Stability & Storage 12 months from date of receipt reconstitution,
Product Specification
| Host | Rabbit |
| Synonyms | Thyroid peroxidase |
| Immunogen | Synthetic Peptide |
| Location | Membrane |
| Accession | P07202 |
| Clone Number | SDT-420-57 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | IHC-P |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| IHC-P | 1:1000 |
Background
Thyroid peroxidase (TPO) is located on the apical free surface of thyroid epithelial cells and directly participates in the oxidation of iodine, iodization of tyrosine, and coupling of iodinated tyrosine in thyroid cyst cells. It is a key enzyme in the synthesis of thyroid hormones. High expression of TPO is observed in normal, proliferative, and most benign thyroid tissues, while significant reduction is observed in malignant thyroid tumors; In pathology, it mainly assists in the diagnosis of goiter and thyroid cancer, and is widely expressed in normal thyroid and benign thyroid lesions. The expression of thyroid cancer is reduced, but the specificity and sensitivity for distinguishing between benign and malignant thyroid tumors are not high.
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