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Description
Cleaved Caspase-8 (Asp387) Recombinant Rabbit mAb (S-2953)Product Specification Host Rabbit Antigen Cleaved Caspase 8 (Asp387) Synonyms CASP 8; Casp8 Location Cytoplasm, Nucleus Accession O89110 Clone Number S 2953 Antibody Type Recombinant mAb Isotype IgG Application WB, ICC Reactivity Ms Purification Protein A Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03% Proclin 300 Stability & Storage 12 months from date of receipt
Product Specification
| Host | Rabbit |
| Antigen | Cleaved Caspase-8 (Asp387) |
| Synonyms | CASP-8; Casp8 |
| Location | Cytoplasm, Nucleus |
| Accession | O89110 |
| Clone Number | S-2953 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, ICC |
| Reactivity | Ms |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:2000 | Ms |
| ICC | 1:500 | Ms |
Background
Cleaved Caspase-8 (Asp387) is the ~18 kDa C-terminal catalytic fragment generated by autoproteolysis at Asp387 during death-receptor-mediated apoptosis, retaining the active-site cysteine and small subunit that, once released from the DISC and freed from its prodomain, forms a heterotetrameric protease capable of cleaving downstream caspases and substrates such as Bid, thereby amplifying the extrinsic apoptotic signaling cascade.
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