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Description
GM-CSFR α His Tag Protein, MouseProduct Specification Species Mouse Synonyms GMR, CD116, CSF2R, SMDP4 Accession Q00941 Amino Acid Sequence Leu30 Pro327, with C 8*His Expression System HEK293 Molecular Weight 44 60kDa Purity >95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4 Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after rapid centrifugation. Stability
Product Specification
| Species | Mouse |
| Synonyms | GMR, CD116, CSF2R, SMDP4 |
| Accession | Q00941 |
| Amino Acid Sequence | Leu30-Pro327, with C-8*His |
| Expression System | HEK293 |
| Molecular Weight | 44-60kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference |
1、Prevost J M. et al. (2002) Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) and Inflammatory Stimuli Up-Regulate Secretion of the Soluble GM-CSF Receptor in Human Monocytes: Evidence for Ectodomain Shedding of the Cell Surface GM-CSF Receptor α Subunit. J Immunol. 169(10): 5679-5688. 2、Cao Y. et al. (2007) Angiogenesis modulates adipogenesis and obesity. J Clin Invest. 117(9): 2362-2368. 3、Fleetwood A J. et al. (2005) Functions of Granulocyte-Macrophage Colony-Stimulating Factor. Crit Rev Immunol. 25(5): 405-428. |
Background
GM-CSF receptor alpha is a member of the cytokine family of receptors. GM-CSF receptor alpha is found in the pseudoautosomal region of the X and Y chromosomes. GM-CSF receptor alpha has different isoform, with some of the isoforms being membrane-bound and others being soluble. Soluble GM-CSF receptor alpha subunit is a soluble isoform of the GMR alpha that is believed to arise exclusively through alternative splicing of the GMR alpha gene product. The sGMR alpha mRNA is expressed in a variety of tissues, but it is not clear which cells are capable of secreting the protein. Hereditary pulmonary alveolar proteinosis (hPAP) is a rare disorder of pulmonary surfactant accumulation and hypoxemic respiratory failure caused by mutations in GM-CSF receptor alpha, which results in reduced GM-CSF-dependent pulmonary surfactant clearance by alveolar macrophages. While no pharmacologic therapy currently exists for hPAP, it was recently demonstrated that endotracheal instillation of wild-type or gene-corrected mononuclear phagocytes results in a significant and durable therapeutic efficacy in a validated murine model of hPAP.
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4.2 ★★★★★
Based on 29 reviews
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Product Reviews
★★★★★ 4
A comfortable good looking light turtleneck knit shirt, great as under garment.
Color: All Black, Size: Medium
When I first tried on the COOFANDY Men’s Mock Turtleneck Sweater, you notice the odd contrast between the turtleneck feel and the short sleeve feel together at the same time. Once you get past that it feels and looks great. Personally, I will wear this under a blazer or jacket and from time to time on its own. I really like the look of it under a jacket. Up until now I don't have any mock turtlenecks but they are fashionable in a country club attire kind of way so I will be able to put this to good use.
The100% polyester knit should be fairly stain resistant. The washing instructions call for hand washing and lay flat drying or cool iron, or dry cleaning.
The cut us slightly different than most of my other shirts. Not bad, just a little different. The sleeves are a little shorter than I expected. They look fine when worn but just feel a little shorter than my other shirts. The mock turtleneck is lightly snug and still comfortable. Again, I think the best look for this is under a sports jacket, but I can see younger men wearing it alone on a regular basis. the mock collar has a cool look to it and seems to contemporize whatever I am wearing.
I like this sweater; it is lightweight and can be worn year-round. I think it will compliment just about any man’s wardrobe as well.
The fit is good. I am 5'10 and weight178 and have on a large.
Reasonably priced.
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Reviewed in the United States on June 2, 2026
★★★★★ 5
Perfect dress shirt. I bought like 7 of them.
Color: All White, Size: XX-Large
Perfect fit and can be stretched if need it. Super light fabric so its not to hot to wear in the summer. Absoluteky love it.
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Reviewed in the United States on April 27, 2026
★★★★★ 5
Runs True To Size
Color: All Black, Size: XX-Large
Excellent quality! Fits great. I’m very pleased. A+++
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Reviewed in the United States on April 26, 2026
★★★★★ 3
Nice style but somewhat abrasive.
Color: Pat5 White Striped, Size: X-Large
The fit was perfect. However, the material for a mock turtle is rather abrasive on my neck, and it wasn’t as comfortable as I was hoping it to be.
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Reviewed in the United States on May 7, 2026
★★★★★ 5
Must have wardrobe ad
Color: Striped Black, Size: Large
Great fit high quality garment. I get lots of compliments on it
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Reviewed in the United States on April 22, 2026