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Description
GBP5 Rabbit Polyclonal AntibodyProduct Specification Host Rabbit Antigen GBP5 Synonyms Guanylate binding protein 5; GBP TA antigen; GTP binding protein 5 (GBP 5); Guanine nucleotide binding protein 5 Immunogen Recombinant Protein Location Cytoplasm Accession Q96PP8 Antibody Type Polyclonal antibody Isotype IgG Application WB, IHC P Reactivity Hu, Ms Purification Immunogen Affinity Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40%
Product Specification
| Host | Rabbit |
| Antigen | GBP5 |
| Synonyms | Guanylate-binding protein 5; GBP-TA antigen; GTP-binding protein 5 (GBP-5); Guanine nucleotide-binding protein 5 |
| Immunogen | Recombinant Protein |
| Location | Cytoplasm |
| Accession | Q96PP8 |
| Antibody Type | Polyclonal antibody |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms |
| Purification | Immunogen Affinity |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:2000 | Hu,Ms |
| IHC-P | 1:500-1:1000 | Hu,Ms |
Background
GBP5 (Guanylate-Binding Protein 5) is a ~67 kDa interferon-inducible large GTPase that polymerizes on membranes and cytosolic surfaces to exert antimicrobial and inflammatory signaling functions; upon pathogen recognition it catalyzes GTP hydrolysis, oligomerizes into coat-like structures that destabilize bacterial or parasitophorous vacuole membranes, recruits the NLRP3 inflammasome via direct CARD-CARD interaction to drive caspase-1–dependent IL-1β/IL-18 maturation, and modulates autophagy and pyroptosis, thereby acting as a critical cytosolic pattern recognition receptor that links innate immunity to cell-autonomous defense against bacteria, viruses, and protozoa while its dysregulation contributes to autoinflammatory diseases and cancer.
Shipping Notes
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Exchange/Return Notes
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