SKU: 54264340500

Invivo anti-mouse 4-1BB (CD137) Recombinant mAb

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Description

Invivo anti-mouse 4-1BB (CD137) Recombinant mAbProduct Specification Host Rat Antigen 4 1BB (CD137) Synonyms Tumor necrosis factor receptor superfamily member 9; 4 1BB ligand receptor; T cell antigen 4 1BB; Ila; Ly63; Tnfrsf9 Location Cell membrane Accession P20334 Antibody Type Recombinant mAb Application in vivo 4 1BB stimulation, in vitro 4 1BB stimulation Reactivity Ms Purification Protein A Concentration 5 mg ml Purity >95% Determined by SEC HPLC Endotoxin <2EU mg Conjugation Unconjugated

Product Specification


Host Rat
Antigen 4-1BB (CD137)
Synonyms Tumor necrosis factor receptor superfamily member 9; 4-1BB ligand receptor; T-cell antigen 4-1BB; Ila; Ly63; Tnfrsf9
Location Cell membrane
Accession P20334
Antibody Type Recombinant mAb
Application in vivo 4-1BB stimulation, in vitro 4-1BB stimulation
Reactivity Ms
Purification Protein A
Concentration 5 mg/ml
Purity >95% Determined by SEC-HPLC
Endotoxin <2EU/mg
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS pH7.4
Stability & Storage

12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Dilution


application dilution species
WB 1:1000 Ms

Background

4-1BB (CD137, TNFRSF9) is a 39 kDa inducible costimulatory receptor expressed on activated T, NK, NKT and dendritic cells that, upon engagement by its trimeric ligand 4-1BBL or agonistic antibodies, recruits TRAF1/2 to trigger NF-κB, MAPK and PI3K–Akt signaling cascades, thereby enhancing proliferation, survival, cytokine production and cytotoxicity of CD8⁺ and CD4⁺ T cells and NK cells; its expression is tightly regulated (peaking 24–72 h post-activation and restrained by PD-1/CTLA-4 pathways) and its therapeutic agonism is exploited in immuno-oncology to overcome tumor-induced exhaustion, while antagonists are explored for autoimmune diseases.

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SKU: 54264340500

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4.6 ★★★★★
Based on 12 reviews
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Verified Purchase
4bonbon
Carnegie, US
★★★★★ 1
Tip will not stay saturated with color
Color: Honey Brown, Size: 1 Count (Pack of 1)
This is a pen with a nice felt tip. First time I used it, it glided on nicely. Second time used about it a week later, tip was dry and no matter how I tried, it would not saturate and provided no color. I even tried storing it with the tip facing down to make the color flood to the tip, but even after several days of standing it up that way, tip was still dry. What a waste of money. I just ordered their Easy Brow and Fill Tool, which is a stick of color that winds in and out and so far like it very much. Would recommend that and not this ink pen.
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Reviewed in the United States on November 30, 2022
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Verified Purchase
Lisa Gagliardi
Dallas, US
★★★★★ 5
Always Perfect!
Color: Rich Brown, Size: 1 Count (Pack of 1)
The best brow liner I have ever used. My eyebrows have thinned over the years because of a thyroid condition and I have been drawing them on since I had was in my thirties. I believe it really retains my youth and the fact that this is a liquid helps me keep the hairs in place that I already have up there. I do not go anywhere without my eyebrow liner. Add this to your makeup kit! You will thank me.
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Reviewed in the United States on January 1, 2026
T
Verified Purchase
Tracy
New York, US
★★★★★ 5
Easy To Use
Color: Soft Brown, Size: 1 Count (Pack of 1)
Easy to use. Looks natural. Great product. I definitely recommend it.
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Reviewed in the United States on December 28, 2025
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Verified Purchase
Kathryn Roberts
Cuba, US
★★★★★ 5
Great Brow Pen
Color: Dark Brown, Color: Dark Brown
I love this brow pen; it’s my favorite brow product I’ve ever used. If you aren’t already here because of Katie Jane Hughes on Instagram, I recommend searching her (@katiejanehughes) and she has an instastory highlight about how she uses this pen. I find it’s extremely important to store these pens upside down to allow the “ink” to travel down to the brush, and also to keep the brush pointed down as you use feathering strokes to paint the shape and hairs you want. The faster you work, the better; some people say the pen dries out, though I find I have plenty of time for both brows, especially if I’m using more than one color. You don’t need to use a primer in advance of using these pens (some peoples he trouble if they DO use primer; something about the slippiness makes it difficult for the pen to stick. I’ve never had that issue myself but if you’re struggling try without primer). I also tend to use a brow gel on top of this, but only to wrangle my brow hairs into one direction. You certainly don’t need to. I’ve attached some swatches, since I had a really hard time finding any online. The main difference between “soft black” and “dark brown” is that the dark brown has a warm undertone and is much more opaque than soft black in my opinion. The idea is to use short, light strokes to apply this, so nothing will be too strong unless you want it to be. I tend to go in with soft black first to get the shape I want at the arch and to do some filling in, then I use medium brown on the inside of my brows and also to fill in, and then I use dark brown last just where I need some extra coverage. I certainly don’t recommend being this extra; I bought the colors to see what they looked like and found that I like the dimension of using multiples and also that it helps ensure my pens don’t dry out at an inopportune time.
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Reviewed in the United States on January 16, 2019
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Verified Purchase
Ren
Omaha, US
★★★★★ 5
my Holy Grail Brow product thank you Katie Jane Hughes
Color: Medium Brown
This is my 3rd or 4th? re-order. I don't know what I will do if it gets discontinued for any reason:( I have very sparse , light brows. This is the only thing in the world that has ever let me make realistic brow hairs, with a small learning curve that don't look drawn on, or fade during the day. The pen will dry out if not left stored upside down. It lasts me at least a few months. I'm always ordering another one before it runs out just so that I'll have a back up. Thank you allure! Glossier has a version of this, but it's less product for more money and the tip isn't a thin as this one. I have even ordered this for friends, it's that good.
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Reviewed in the United States on February 6, 2020

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