SKU: 56686352695

IL-18BP Fc Chimera Protein, Human

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Description

IL-18BP Fc Chimera Protein, HumanProduct Specification Species Human Antigen IL 18BP Synonyms IL18BP, Tadekinig alfa Accession O95998 2 Amino Acid Sequence Thr31 Gly194, with C terminal Human IgG1 Fc

Product Specification


Species Human
Antigen IL-18BP
Synonyms IL18BP, Tadekinig-alfa
Accession O95998-2
Amino Acid Sequence

Thr31-Gly194, with C-terminal Human IgG1 Fc TPVSQTTTAATASVRSTKDPCPSQPPVFPAAKQCPALEVTWPEVEVPLNGTLSLSCVACSRFPNFSILYWLGNGSFIEHLPGRLWEGSTSRERGSTGTQLCKALVLEQLTPALHSTNFSCVLVDPEQVVQRHVVLAQLWAGLRATLPPTQEALPSSHSSPQQQGIEGRMDPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
Expression System HEK293
Molecular Weight 53-76kDa
Purity ＞95% by SDS-PAGE
Endotoxin <0.1EU/μg
Conjugation Unconjugated
Tag Human Fc
Physical Appearance Lyophilized Powder
Storage Buffer PBS, pH7.4
Reconstitution Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference

1. Review Front ImmunoQl . 2013 Oct 8;4:289.

Background

Interleukin-18 binding protein, also known as IL-18BP and tadekinig-alfa, is a secreted glycoprotein that contains an Ig-like C2-type domain. IL-18BP is a cytokine receptor that belongs to the interleukin 1 receptor family. IL18BP shares many characteristics with soluble cytokine receptors of the IL1 family in that the protein exhibits specificity for IL18, belongs to the immunoglobulin-like class of receptors and has limited amino acid sequences with those of the IL1 receptor type II. According to the other study, IL1R9 is evolutionarily related to IL18BP and may function as an IL-18 receptor. Plasma il-18 /IL18BP levels increase during disease activity, suggesting that it may play a role in the pathogenesis of ITP.

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Exchange/Return Notes
  • We offer a 30-day return/exchange service after receiving.
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SKU: 56686352695

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4.1 ★★★★★
Based on 24 reviews
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Verified Purchase
PikaJoon
Dallas, US
★★★★★ 5
Haru LOVES this toy!
I recently purchased the Amazon Basics Hide and Seek Squeaky Dog Plush Toy, Rabbit and Carrot 5 Pack, and it has been an absolute hit with my dog Haru! This set has quickly become his favorite playtime activity, and it's easy to see why. From the moment I introduced Haru to the plush toys, he was hooked! The rabbit and carrot design is not only adorable but also adds an element of excitement and curiosity for him. The toys' quality is impressive, with sturdy stitching that has held up well to Haru's enthusiastic play style. The "hide and seek" aspect of the toys is brilliant. Each plush toy contains squeakers, which immediately captured Haru's attention. He thoroughly enjoys searching for the source of the squeaky sound and then triumphantly "catching" the rabbit or carrot. It's like a mini-game that keeps him mentally stimulated and entertained. One of the best things about this 5-pack set is the variety it offers. Haru never gets bored because he can alternate between the different plush toys, and each one presents a new challenge for him. Whether he's "hunting" the rabbit or "nibbling" on the carrot, his excitement is contagious! Furthermore, I appreciate how these toys keep Haru engaged for a good amount of time. As a busy dog owner, it's essential to have toys that can entertain him while I'm occupied with other tasks. The Hide and Seek Squeaky Dog Plush Toy accomplishes this perfectly, giving me some peace of mind knowing Haru is happily occupied.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on July 21, 2023
J
Verified Purchase
Jillian
Alexandria, US
★★★★★ 5
Great toy
Great size for a medium to large dog and a good value overall. The carrot foliage is made of felt and can tear easily, but the carrot body and bunnies have typical toy durability. The bunnies include squeakers that are softer and not high-pitched. The holes are sized well—small enough that the bunnies don’t fall out on their own. Even with only a few stuffed inside, they stay put until your dog pulls them out.
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Reviewed in the United States on November 30, 2025
W
Verified Purchase
W. Willard
Lexington, US
★★★★★ 5
I was shocked by how much my daughter's puppy enjoyed this toy!
I've bought two of these — one for my grand puppy to use when she's at my house, and another for her to keep at her house. I was shocked that she actually seems to enjoy playing with this toy! She hunts out all the bunnies and then brings the carrot to me to refill. I refill it, and then she takes the refilled carrot back to her spot and hunts them all out again. If I can't find one of the bunnies (because it's gotten stuck in the couch cushion, for example), I ask her "where's the bunny?" and she helps me find it! This dog is a ferocious chewer but she doesn't chew these toys! It's like she instinctively knows they are for hunting, not chewing. As a result, they have lasted a long time and provide hours of quality fun. Great value!
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Reviewed in the United States on April 7, 2026
W
Verified Purchase
WhiteheadsArt
West Palm Beach, US
★★★★★ 5
My Iggies LOVE this toy. Buy it!!!!!
As a new dog mom to Italian greyhounds, I wasn’t sure if they’d like this, but it is their favorite toy!!!! They LOVE playing with the rabbits, chewing on them, squishing them, flinging them and chasing them. My one iggy likes to chew on the carrot and stick her nose in it when it’s empty. I find the rabbits around the house. So cute and seems to be well made. Definitely worth the cost.
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Reviewed in the United States on March 18, 2026
A
Verified Purchase
Amazon Customer
Grantham, US
★★★★★ 5
Very cute and well loved dog toy.
I have two maltese rescue dogs. One if still a puppy and the other is almost 5 years old. The youngest one is a chewer and goes through toys removing whatever she can as soon as she can. This is a VERY cute toy and comes with the 4 cute bunnies inside. My older dog loves to take the bunnies and cuddle them in her bed. So far the chewer has not been able to take them apart and for that I am very pleased. Very well made, stiched well. I was reluctant at first to purchase because of price, but I believe this is good value for your money.
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Reviewed in the United States on February 1, 2026

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