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Description
Scavenging Receptor SR-BI Recombinant Rabbit mAb (S-1736-15)Product Specification Host Rabbit Antigen Scavenging Receptor SR BI Synonyms Scavenger receptor class B member 1; SRB1; CD36 and LIMPII analogous 1 (CLA 1); CD36 antigen like 1; Collagen type I receptor; thrombospondin receptor like 1; SR BI; CD36; CD36L1; CLA1; SCARB1 Immunogen Recombinant Protein Location Cell membrane Accession Q8WTV0 Clone Number S 1736 15 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms, Rt
Product Specification
| Host | Rabbit |
| Antigen | Scavenging Receptor SR-BI |
| Synonyms | Scavenger receptor class B member 1; SRB1; CD36 and LIMPII analogous 1 (CLA-1); CD36 antigen-like 1; Collagen type I receptor; thrombospondin receptor-like 1; SR-BI; CD36; CD36L1; CLA1; SCARB1 |
| Immunogen | Recombinant Protein |
| Location | Cell membrane |
| Accession | Q8WTV0 |
| Clone Number | S-1736-15 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | HepG2, THP-1, NIH/3T3, rat liver |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:5000 | Hu, Ms, Rt |
| IHC-P | 1:1000 | Hu, Ms, Rt |
| ICC | 1:500 | Hu |
Background
Scavenger receptor class B type I (SR-BI) is a versatile and physiologically significant HDL receptor that plays a crucial role in cholesterol homeostasis and lipoprotein metabolism. It is a cell surface glycoprotein highly expressed in the liver, steroidogenic tissues, endothelium, and other tissues. SR-BI mediates the selective uptake of cholesterol esters from HDL particles into cells through hydrophobic channels without internalizing the entire lipoprotein, facilitating reverse cholesterol transport. This process helps remove excess cholesterol from peripheral tissues and promotes its excretion via bile acids, thus exerting anti-atherosclerotic effects. Additionally, SR-BI is involved in various biological functions, including regulation of inflammation, endothelial cell function, and lipid metabolism in macrophages. Its dysfunction or genetic mutations are associated with increased cardiovascular risk and altered HDL metabolism.
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