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Description
Choline Acetyltransferase/ChAT Recombinant Rabbit mAb (S-2561-17)Product Specification Host Rabbit Antigen Choline Acetyltransferase ChAT Synonyms Choline O acetyltransferase; CHOACTase; Choline acetylase Immunogen Synthetic Peptide Location Cytoplasm, Nucleus, Synapse Accession P28329 Clone Number S 2561 17 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu, Ms, Rt Positive Sample Human brain, mouse brain, rat brain Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated
Product Specification
| Host | Rabbit |
| Antigen | Choline Acetyltransferase/ChAT |
| Synonyms | Choline O-acetyltransferase; CHOACTase; Choline acetylase |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Nucleus, Synapse |
| Accession | P28329 |
| Clone Number | S-2561-17 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | Human brain, mouse brain, rat brain |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Ms, Rt |
| IHC-P | 1:1000 | Hu, Ms, Rt |
Background
Choline acetyltransferase (ChAT) is a 69-kDa cytosolic transferase enzyme encoded by the CHAT gene that catalyzes the single-step acetylation of choline with acetyl-CoA to synthesize the neurotransmitter acetylcholine (ACh) in the presynaptic terminals of cholinergic neurons throughout the central and peripheral nervous systems; it is synthesized in the soma, trafficked to nerve endings via axoplasmic flow, exists in soluble and membrane-bound pools, displays alternative splicing that can generate larger nuclear variants, and is considered the most specific phenotypic marker for cholinergic neurons whose functional integrity underlies memory, cognition, arousal, and motor control, while its loss or dysfunction is closely linked to the cholinergic deficits seen in Alzheimer’s disease, amyotrophic lateral sclerosis, schizophrenia, and other neurodegenerative or neuropsychiatric disorders .
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