SKU: 6469880279

PE Mouse Anti-human HLA-ABC Antibody (S-R526)

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Description

PE Mouse Anti-human HLA-ABC Antibody (S-R526)Product Specification Host Mouse Antigen HLA ABC Synonyms HLA class I histocompatibility antigen; A alpha chain; Human leukocyte antigen A (HLA A); HLA class I histocompatibility antigen; B alpha chain; Human leukocyte antigen B (HLA B); HLA class I histocompatibility antigen, C alpha chain; HLA Cw; Human leukocyte antigen C Location Cell membrane Accession P04439P01889P10321 Clone Number S R526 Antibody Type Mouse mAb Isotype IgG2a,k Application FCM

Product Specification


Host Mouse
Antigen HLA-ABC
Synonyms HLA class I histocompatibility antigen; A alpha chain; Human leukocyte antigen A (HLA-A); HLA class I histocompatibility antigen; B alpha chain; Human leukocyte antigen B (HLA-B); HLA class I histocompatibility antigen, C alpha chain; HLA-Cw; Human leukocyte antigen C
Location Cell membrane
Accession P04439、P01889、P10321
Clone Number S-R526
Antibody Type Mouse mAb
Isotype IgG2a,k
Application FCM
Reactivity Hu
Positive Sample human peripheral blood Leukocytes
Purification Protein A
Concentration 0.2 mg/ml
Conjugation PE
Physical Appearance Liquid
Storage Buffer

PBS, 1% BSA, 0.3% Proclin 300

Stability & Storage

12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Dilution


application dilution species
FCM 1.25μl per million cells in 100μl volume Hu

Background

HLA-ABC (also termed HLA class I classical heavy chains A, B, and C) are 44 kDa type I transmembrane glycoproteins encoded within the major histocompatibility complex on chromosome 6p21.3; each non-covalently associates with the invariant light chain β2-microglobulin (12 kDa) to form a peptide-binding heterodimer that is constitutively expressed on nearly all nucleated cells. These molecules serve as the principal conduit for presenting endogenously derived 8–11-mer peptides to CD8⁺ cytotoxic T lymphocytes, thereby orchestrating immune surveillance against intracellular pathogens, tumors, and transplanted tissues. Polymorphic residues concentrated in the α1 and α2 domains create an extraordinary diversity (thousands of alleles catalogued in the IPD-IMGT/HLA database), which underpins population-level resistance to infection yet constitutes the primary barrier to solid-organ and hematopoietic stem-cell transplantation through allorecognition. Beyond antigen presentation, HLA-ABC interacts with NK-cell inhibitory receptors (KIR and LILRB1) to calibrate natural killer cell responses, and its surface levels are dynamically modulated by cytokines such as interferon-γ, viral immune evasion proteins (e.g., HIV Nef, CMV US2/US11), and oncogenic signaling pathways, making quantitative HLA-ABC expression a prognostic biomarker in cancer immunotherapy.

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Exchange/Return Notes
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SKU: 6469880279

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4.2 ★★★★★
Based on 30 reviews
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Product Reviews
C
Verified Purchase
Chentao
Belleville, US
★★★★★ 5
doggy toy chicken leg
Color: Yellow - Fried Chicken Leg
I bought this chicken leg toy for my dog and it quickly became one of his favorites. The yellow top part has two different sections — the very top makes a crinkly sound like paper when he bites it, and the middle squeaks when he chews or presses on it, which really keeps him interested. The white bottom part is super soft and easy for me to hold, so it’s great for playing tug or just interacting with him. The size is perfect for small dogs, but it might feel a bit small for larger breeds — that said, the material quality is really nice. Overall, it feels well made, fun, and keeps my dog entertained without getting bored. Definitely a good buy.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on January 4, 2026
X
Verified Purchase
xmiki
West Palm Beach, US
★★★★★ 4
Fun, engaging, and cute toy for dogs!
Color: Yellow - Fish Skewer, Color: Yellow - Fish Skewer
I got the fried fish toy for my dog. So far, he really enjoys the squeaking noise and comes running every time he hears it. The toy material is pretty thick and is holding up well during playtime. The size of this toy is perfect for my small dog but it might be a bit small for larger dogs. Overall it's a fun and super cute toy for my pets that's become a favorite!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on December 31, 2025
G
Verified Purchase
Gin Fu
New York, US
★★★★★ 5
Fun enrichment
Color: Yellow - Fish Skewer, Color: Yellow - Fish Skewer
Bought this to keep my dog busy while I’m out, and surprisingly it works. It’s soft, lightweight, and he was interested right away. Hiding treats inside turns it into a sniffing challenge that keeps him occupied longer than expected. The squeaker does its job, and the material feels gentle, but this is not for heavy chewers. If your dog destroys toys for sport, proceed with caution. Overall, it’s a fun enrichment toy that helps with boredom. Great for light to moderate play and dogs who don’t choose violence every day.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on January 7, 2026
C
Verified Purchase
chen
Carnegie, US
★★★★★ 5
Really cute and great for photos
Color: Yellow - Fried Chicken Leg, Color: Yellow - Fried Chicken Leg
This drumstick plush toy is super cute and looks great in pictures. My dog liked it right away and keeps carrying it around. It’s soft, lightweight, and the size is just right. We’ve already taken a few fun photos with it, and it would also make a nice little gift for someone with a dog. Simple, well made, and definitely worth it.
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Reviewed in the United States on January 4, 2026
B
BarbaraAnn
Boise, US
★★★★★ 2
Don't Bother Unless You Have Something The Size of a Chihuahua
Color: Yellow - Fried Chicken Leg
Title is definitely deceiving. We have 2 Pitbulls and a Bull Terrier. They simply looked at this thing and it blew into pieces. These are more for smaller dogs. I wouldn't even say medium. It was just a big disappointment. I was excited to give them this toy, until it arrived and I saw how small it was.
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Reviewed in the United States on January 3, 2026

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