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Description
Phospho-RIP3 (Ser232) Recombinant Rabbit mAb (S-1134-6)Product Specification Host Rabbit Antigen Phospho RIP3 (Ser232) Synonyms Receptor interacting serine threonine protein kinase 3; RIP like protein kinase 3; Receptor interacting protein 3 (RIP 3); RIP3; RIPK3 Immunogen Synthetic Peptide Location Cytoplasm, Nucleus Accession Q9Y572 Clone Number S 1134 6 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Ms Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical
Product Specification
| Host | Rabbit |
| Antigen | Phospho-RIP3 (Ser232) |
| Synonyms | Receptor-interacting serine/threonine-protein kinase 3; RIP-like protein kinase 3; Receptor-interacting protein 3 (RIP-3); RIP3; RIPK3 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Nucleus |
| Accession | Q9Y572 |
| Clone Number | S-1134-6 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Ms |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| Dot Blot | 1:1000 | |
| WB | 1:1000 | Ms |
Background
Phospho-RIP3 (Ser232) is a phosphorylated form of the receptor-interacting serine/threonine-protein kinase 3 (RIPK3), which plays a crucial role in regulating necroptosis, a form of programmed cell death. When phosphorylated at Ser232, RIPK3 is activated and forms a necrosis-inducing complex with other proteins such as RIPK1 and MLKL. This phosphorylation event is essential for the recruitment and activation of MLKL, which subsequently executes necroptosis by causing plasma membrane damage and calcium influx. Additionally, Phospho-RIP3 (Ser232) can also participate in apoptosis regulation and metabolic processes in certain cell types.
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