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Description
CXCL10/IP-10 Recombinant Rabbit mAb (S-1910-59)Product Specification Host Rabbit Antigen CXCL10 IP 10 Synonyms C X C motif chemokine 10; 10 kDa interferon gamma induced protein (Gamma IP10; IP 10); Small inducible cytokine B10; INP10; SCYB10 Immunogen Recombinant Protein Location Secreted Accession P02778 Clone Number S 1910 59 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid
Product Specification
| Host | Rabbit |
| Antigen | CXCL10/IP-10 |
| Synonyms | C-X-C motif chemokine 10; 10 kDa interferon gamma-induced protein (Gamma-IP10; IP-10); Small-inducible cytokine B10; INP10; SCYB10 |
| Immunogen | Recombinant Protein |
| Location | Secreted |
| Accession | P02778 |
| Clone Number | S-1910-59 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
Background
CXCL10, also known as interferon γ-induced protein 10 kDa (IP-10), is a cytokine belonging to the CXC chemokine family. It exerts its biological effects by binding to the CXCR3 receptor, which is predominantly expressed on activated T cells, B cells, natural killer (NK) cells, dendritic cells, and macrophages. CXCL10 is a pleiotropic molecule with diverse functions, including promoting the chemotaxis of CXCR3+ cells, inducing apoptosis, regulating cell growth and proliferation, and modulating angiogenesis in infectious, inflammatory, and cancerous conditions. It is secreted by various cell types, such as leukocytes, epithelial cells, and fibroblasts, in response to IFN-γ stimulation. The CXCL10 gene was first isolated in 1985 and encodes a 12 kDa protein with two internal disulfide cross-bridges. Its expression levels are associated with immune responses, tissue damage, and tumor formation, making it a significant factor in both innate and adaptive immunity.
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