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Description
TGFBR2 Recombinant Rabbit mAb (S-1711-55)Product Specification Host Rabbit Antigen TGFBR2 Synonyms TGF beta receptor type 2; TGFR 2; TGF beta type II receptor; Transforming growth factor beta receptor type II (TGF beta receptor type II; TbetaR II) Immunogen Synthetic Peptide Location Cell membrane, Secreted Accession P37173 Clone Number S 1711 55 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu, Ms Positive Sample NIH 3T3 Purification Protein A Concentration 0. 5
Product Specification
| Host | Rabbit |
| Antigen | TGFBR2 |
| Synonyms | TGF-beta receptor type-2; TGFR-2; TGF-beta type II receptor; Transforming growth factor-beta receptor type II (TGF-beta receptor type II; TbetaR-II) |
| Immunogen | Synthetic Peptide |
| Location | Cell membrane, Secreted |
| Accession | P37173 |
| Clone Number | S-1711-55 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms |
| Positive Sample | NIH/3T3 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms |
| IHC-P | 1:250 | Hu |
Background
TGFBR2, also known as transforming growth factor-beta receptor type 2, is a transmembrane protein that plays a crucial role in cellular signaling. It contains a protein kinase domain and forms a heterodimeric complex with TGF-beta receptor type-1, binding to TGF-beta ligands to initiate signal transduction. This receptor complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of genes involved in cell proliferation, differentiation, apoptosis, wound healing, and immunosuppression. TGFBR2 is essential for maintaining cellular homeostasis and preventing uncontrolled cell growth, thus acting as a tumor suppressor. Mutations in the TGFBR2 gene are associated with various disorders, including Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and familial thoracic aortic aneurysm and dissection. Additionally, aberrations in TGFBR2 signaling are implicated in the development of multiple types of tumors.
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