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Description
Mouse Anti-Human GPR183 (EBI2) Antibody (S-3016)Product Specification Host Mouse Antigen GPR183 (EBI2) Synonyms G protein coupled receptor 183; Epstein Barr virus induced G protein coupled receptor 2 (EBI2; EBV induced G protein coupled receptor 2; hEBI2) Location Cell membrane Accession P32249 Clone Number S 3016 Antibody Type Mouse mAb Isotype IgG2a,k Application FCM Reactivity Hu Positive Sample Human Peripheral Blood cells Purification Protein A Concentration 2 mg ml Conjugation Unconjugated
Product Specification
| Host | Mouse |
| Antigen | GPR183 (EBI2) |
| Synonyms | G-protein coupled receptor 183; Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2; EBV-induced G-protein coupled receptor 2; hEBI2) |
| Location | Cell membrane |
| Accession | P32249 |
| Clone Number | S-3016 |
| Antibody Type | Mouse mAb |
| Isotype | IgG2a,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | Human Peripheral Blood cells |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1:200 | Hu |
Background
GPR183 (also designated Epstein–Barr virus-induced gene 2, EBI2) is a seven-transmembrane Gαi-coupled GPCR discovered through its strong up-regulation in Epstein–Barr virus–infected Burkitt lymphoma cells; it is expressed on B cells, T cells, dendritic cells and other immune and non-immune cells, binds the oxysterol 7α,25-dihydroxycholesterol (7α,25-OHC) as its most potent endogenous ligand, and drives chemotaxis and positioning of B and T cells within secondary lymphoid organs by sensing oxysterol gradients generated by the enzymes CH25H and CYP7B1; downstream signalling involves calcium mobilisation, ERK1/2 and p38 MAPK activation, β-arrestin recruitment and SRE-mediated transcription, thereby orchestrating adaptive immune responses, while genetic or pharmacologic interference with the GPR183/7α,25-OHC axis leads to impaired antibody production, defective plasma-cell localisation and altered trafficking of innate lymphoid cells, and has implicated the receptor in autoimmune, inflammatory and viral diseases, making GPR183 and its ligand attractive therapeutic targets.
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