SKU: 16578426619

Zoetis INFORCE 3® Respiratory Vaccine

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Description

Zoetis INFORCE 3® Respiratory VaccineRespiratory disease can challenge young calves and dairy cows immediately before and at calving. INFORCE 3 the market leading cattle respiratory vaccine1, is for the vaccination of healthy cattle, including pregnant cows, to help protect against respiratory disease caused by bovine respiratory syncytial virus (BRSV), infectious bovine rhinotracheitis (IBR) virus and parainfluenza3 (PI3) virus. For dairy herds, INFORCE 3 can be used in calves as young

Respiratory disease can challenge young calves and dairy cows immediately before and at calving. INFORCE 3® the market-leading cattle respiratory vaccine1, is for the vaccination of healthy cattle, including pregnant cows, to help protect against respiratory disease caused by bovine respiratory syncytial virus (BRSV), infectious bovine rhinotracheitis (IBR) virus and parainfluenza3 (PI3) virus. For dairy herds, INFORCE 3 can be used in calves as young as 3 days old, at weaning, before moving to group pens, or with cows and heifers at prefreshening.

Indications
Helps protect against respiratory disease caused by BRSV, IBR and PI3.
Available As

Vials

For use with

Beef

Dairy

How it Works

As an intranasal respiratory vaccine, INFORCE 3® causes a local immune response with viral antibodies produced in the nasal passage where BRSV, IBR and PI3 are most likely to enter the animal’s system.

INFORCE 3® is the first commercially-available intranasal respiratory vaccine to help protect against respiratory disease caused by BRSV, while also protecting against IBR and PI3, to help get cattle off to a healthier, more productive start.

INFORCE 3 has a six-month duration of immunity claim for IBR protection, and a single-nostril administration claim. Additional research also demonstrated no maternal antibody interference for IBR and BRSV.2,3

Safe for all ages, types and classes of cattle

INFORCE 3® is safe for use in all types, ages and classes of cattle. INFORCE 3 was demonstrated safe for use in very young, high-stress calves; weaned and high-stress stocker calves; and pregnant heifers and cows.

The Science Behind Effective Control

  • Intranasal administration works with the animal's immune system for fast, effective response
  • Helps prime the immune system for a memory response to subsequent vaccinations as well as disease challenges
  • Contains proprietary, temperature-sensitive IBR and PI3 strains that replicate most effectively in the upper respiratory tract
  • Stimulates interferon release for protection
  • Helps deliver a healthy start for young dairy calves

Proven Respiratory Disease Protection

  • In two different studies, all calves vaccinated with INFORCE 3 survived severe BRSV challenges in which 100% and 90% of unvaccinated controls either died or had to be humanely euthanized.4,5
  • INFORCE 3 was shown to help prevent respiratory disease caused by IBR and PI3 and reduce level and duration of viral shedding caused by IBR and PI3.6-8
  • A study comparing INFORCE 3 and TSV-2® demonstrated that vaccinating cows and heifers with INFORCE 3  prior to freshening helped support overall positive production:
    • 205 pounds more milk per cow per lactation9
    • Increased income per cow9

Directions

Aseptically rehydrate the freeze-dried vaccine with the sterile diluent provided, mix well and administer 2 mL intranasally using a cannula. Place the 2-mL dose in a single nostril or place 1-mL in each nostril. 

Calves vaccinated before the age of 6 months should be revaccinated after 6 months of age to avoid possible maternal antibody interference with immunization. Annual revaccination with a single dose is recommended. 

For further advice on revaccination frequency, consult your veterinarian.

PRECAUTIONS:

  1. Store at 2°-8°C. Prolonged exposure to higher temperatures and/or direct sunlight may adversely affect potency. Do not freeze.

  2. Use entire contents when first opened.

  3. Sterilized syringes should be used to administer this vaccine. Do not sterilize with chemicals because traces of disinfectant may inactivate the vaccine.

  4. Inactivate unused contents before disposal.

  5. Do not vaccinate within 21 days before slaughter.

  6. Contains gentamicin as preservative.

  7. Fetal health risks associated with the vaccination of pregnant animals with modified live vaccines cannot be unequivocally determined during clinical trials conducted for licensure. Appropriate strategies to address the risks associated with modified live vaccine use in pregnant animals should be discussed with a veterinarian.

  8. As with many vaccines, anaphylaxis may occur after use. Initial antidote of epinephrine is recommended and should be followed with appropriate supportive therapy.

References

  1. Based on number of doses and overall sales of respiratory vaccines. Animalytics Segment Data, Biologicals Therapeutic Category, Ending MAT May 2021.
  2. Mahan SM, Sobecki B, Johnson J, et al. Efficacy of Intranasal Vaccination With a Multivalent Vaccine Containing Temperature-Sensitive Modified-Live Bovine Herpesvirus Type 1 for Protection of Seronegative and Seropositive Calves Against Respiratory Disease. J Am Vet Med Assoc. 2016;248(11):1280-1286.
  3. Ellis JA, Gow SP, Mahan S, Leyh R. Duration of Immunity to Experimental Infection With Bovine Respiratory Syncytial Virus Following Intranasal Vaccination of Young Passively Immune Calves. J Am Vet Med Assoc. 2013;243(11):1602-1608.
  4. Data on file, Study Report No. 3131R-60-08-557, Zoetis Inc.
  5. Data on file, Study Report No. 3131R-60-09-669, Zoetis Inc.
  6. Data on file, Study Report No. 3131R-60-08-548, Zoetis Inc.
  7. Data on file, Study Report No. 3131R-60-09-720, Zoetis Inc.
  8. Data on file, Study Report No. 3131R-60-08-568, Zoetis Inc.
  9. Data on file, Study Report No. 10PETINF01, Zoetis Inc.
Shipping Notes
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Exchange/Return Notes
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SKU: 16578426619

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4.4 ★★★★★
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A
Verified Purchase
ali
Charlottesville, US
★★★★★ 5
Good ball for strong chewers
Color: Cheeze Brawl - Large, Color: Cheeze Brawl - Large
My dog loves this ball except the outside fur gets gross really quickly. However, it’s easy to cutoff and underneath is a strong squeaky ball. It’s like two gifts in one. He’s a very heavy chewer and the ball lasts quite a bit.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on December 31, 2025
A
Verified Purchase
Ashton Gibson
Waukegan, US
★★★★★ 5
Take the skin off and get the right size for your dog’s weight!
Color: Panda Bear - Large, Color: Panda Bear - Large
This review is specifically for the panda toy. My dog is a super chewer and will literally go through any normal toy, even the ones labeled for aggressive chewers, within a few hours at most. He’s about to be 10 years old and this is the first time he’s ever had a toy that lasted as long as it has. I wanna mention the outer layer he almost immediately chewed through. To me, it wasn’t worth the fear of him dealing through pieces so I just took the whole “skin” off. However, he’s safely had this for 2 months with no issues and heavy daily chewing until he finally broke it apart. So if you have a super chewer, make sure to get the size appropriate for your dog’s weight and take the “skin” off and you’re left with a quality toy that will stick around! Pictured is a set of 2 new toys of the same variety since he finally chewed through his last batch lol
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 27, 2026
K
Verified Purchase
Kit
Massapequa, US
★★★★★ 4
My dog loves this toy but…
Color: Grey Bear - Large
This toy has many pros and cons, but it’s my dogs all time favorite toy so I have to give it 4 stars. Pro:My German Shepard loves this toy, it has no squeaker and she hates squeakers, so she hasn’t tried to destroy it. It’s the perfect size for a large ball. She likes to throw her toys and this one has a pretty decent bounce to it so she can entertain herself. Cons: the inside is hard rubber, she likes to throw her toys and it hurts when she hits you with it or drops it on your feet. Also a huge hazard to windows and anything breakable.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on July 12, 2025
I
Verified Purchase
ingrid C
Carnegie, US
★★★★★ 5
Pretty awesome chew toy
Color: Grey Bear - Large
This toy is great!! I have a doodle that shreds everything in sight, including durable toys, but this one stood up to the Teddy test! He easily ripped off the ear/feet bits, but the fabric casing hasn’t come off after a week of play, and I expect the rubber toy inside will be even harder to break. This is a fairly heavy toy, so it makes a thunk when it drops and is probably not suitable for small dogs. It has a light squeak that is quiet and infrequent enough to not annoy me, and it’s pretty cute too!! it does get soaked in drool pretty fast (and takes forever to dry), but at this point i’m grateful it lasts long enough to get drooled on at all.
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Reviewed in the United States on September 30, 2025
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a b
Phoenix, US
★★★★★ 3
less than 24 hours :/
Color: Grey Bear - Large, Color: Grey Bear - Large
smaller than i expected but had a strong interior that i was pleasantly surprised with. my lil lady very much enjoyed it, however it lasted less than 24 hours before the poor toy was skinned alive :( she loves plushies and she’s obsessed w his skin after tearing him apart. it does have a solid rubber interior that is still good as a toy, however i was hoping its skin would stay on longer than a day :( overall decent toy, 3 stars for being destroyed so quickly. wouldn’t recommend for strong chewers
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Reviewed in the United States on August 7, 2025

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