SKU: 5942088976

Methylfolate Featuring Quatrefolic - 15 mg, 60 capsules

Sale price$44.99 Regular price$49.99
Save 10%

Pay in installments of $12.50 with ShopPay, AfterPay and Klarna

Shipping Estimate
USA
  • USA
  • CAN

Ships within 48 hours · Estimated delivery Aug 1 - Aug 6

Promo Codes Available:

For Your Every Summer RSVP, with Code: SUMMER15

Description

Methylfolate Featuring Quatrefolic - 15 mg, 60 capsulesFolate is a vital B vitamin that plays a key role in methylationa critical process for DNA synthesis, detoxification, neurotransmitter production, and cardiovascular health. Our formula delivers 5 mg of Quatrefolic, the most advanced and bioavailable form of folate, designed to bypass genetic polymorphisms (such as MTHFR) that impair folic acid metabolism.* Why Quatrefolic? Quatrefolic is the glucosamine salt of (6S) 5 methyltetrahydrofolatethe

Folate is a vital B vitamin that plays a key role in methylation—a critical process for DNA synthesis, detoxification, neurotransmitter production, and cardiovascular health. Our formula delivers 5 mg of Quatrefolic®, the most advanced and bioavailable form of folate, designed to bypass genetic polymorphisms (such as MTHFR) that impair folic acid metabolism.*

Why Quatrefolic®?

Quatrefolic® is the glucosamine salt of (6S)-5-methyltetrahydrofolate—the bioactive form of folate that the body uses directly, without requiring conversion. Unlike folic acid, which must go through multiple enzymatic steps to become active, Quatrefolic® is ready for immediate uptake and use at the cellular level.*

  • Clinically studied for enhanced bioavailability
  • Supports methylation pathways*
  • Supports healthy homocysteine balance*
  • Supports mood and cardiovascular health*
  • Essential for fetal development and reproductive health*

View Certificate of Analysis

Who It's For

This high-dose formula is ideal for individuals with increased folate needs or those with MTHFR gene variants who may have trouble converting folic acid to its usable form.*

How It Works

Folate is required to convert homocysteine into methionine—a process vital for cardiovascular and neurological function. It also supports the production of neurotransmitters like serotonin, dopamine, and norepinephrine, which influence mood and cognition.*

What Makes Ours Better?

  • Longevity Focused: We leverage cutting-edge advancements in aging research to formulate products that address the fundamental causes of aging.*
  • Triple Lab Tested: Every product is tested three times by independent 3rd-party labs to ensure we meet the highest standards.
  • Complete Transparency: In an industry flooded with fake supplements, we stand apart by publishing our 3rd-party lab test results. We’re committed to showing you exactly what’s in every bottle, so you can feel confident in what you’re putting into your body. 
  • USA Manufacturing Excellence: Made in FDA-regulated, GMP-certified facilities in the USA for the highest quality and safety standards.
  • 100-Day Risk-Free Guarantee: We stand behind our products. Not satisfied? Reach out to our Santa Barbara, CA office for a full refund within 100 days – no hassle, no questions.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

References:

1 Bani Soheila, J Caring Sci 2013 
2 Mazza A. et al. Biol Regul Homeost Agents 2016
3 Rima Obeid R., Herrmann W. FEBS Letters 580, 2006
4 Stover Patrick, Curr Opin Biotechnol 2017
Seshadri S. at al. N Engl J Med 2002 
6 Bottiglieri T, J Neurol Neurosurg Psychiatry 2000 
7 Thaler C.J. 2014 
8 Stover PJ. Modern Nutrition in Health and Disease 2012
9 Tinelli C, Di Pino A Front. Nutr. 2019

Supplement Facts
Serving Size: 1 Capsule
Servings Per Container: 60
Amount Per Serving %DV
Folate (as Quatrefolic® (6S)-5-Methyltetrahydrofolate, glucosamine salt) 25000 mcg DFE (15 mg) 6250%
* Daily Value (DV) based on a 2,000 calorie diet.
REV. 03.24
  • OTHER INGREDIENTS: Microcrystalline cellulose, vegetable capsule.
  • DOES NOT CONTAIN: Dairy, egg, soy, wheat, gluten, corn, fish, shellfish, tree nuts, peanuts.
  • SUGGESTED DAILY USE: Take 1 capsule daily, or as directed by your healthcare professional.
  • CAUTION: Not intended for use if you are pregnant or nursing. Not formulated for use in children. If you have a medical condition or are taking medications, consult with your healthcare professional before using this product. 
  • NOTE: Store in a cool, dry place, away from direct sunlight. Do not use if tamper-evident packaging is broken. KEEP OUT OF REACH OF CHILDREN.
Shipping Notes
  • Free Standard Shipping on $100+ Orders to the USA.
  • Except Preorder products are shipped in 48 hours.
  • Delivery to the USA:
  1. Standard Shipping : 3-10 business days
  • If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
  • We offer a 30-day return/exchange service after receiving.
  • Final sale items are not eligible for returns or exchanges.
  • To process your return/exchange, please contact us at [email protected]
  • Please click here for more details>>> Return & Exchange Policy
SKU: 5942088976

Discover Niche Categories That Outsell

Top-Converting Item to Boost Your Average Order

4.7 ★★★★★
Based on 9 reviews
Sort
Highest Rating
Newest First
Oldest First
Product Reviews
K
Verified Purchase
Kathryn
Port Orchard, US
★★★★★ 5
Best chew toy ever!
Size: Small, Color: Textured Ring, Size: Small, Color: Textured Ring
This bone is indestructible. Finally a toy that doesn't get chewed up to pieces.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 5, 2026
L
Verified Purchase
Laurel
Draper, US
★★★★★ 5
Heavy duty, excellent quality
Size: Small, Color: Textured Ring, Size: Small, Color: Textured Ring
I trust the Nylabone brand and would not buy a cheap substitute to save a few bucks. This ring is heavy duty. I got it for our 9-week-old puppy and it keeps her interested and entertained with all the little nubs. She uses it more as a toy than something to chew on, tossing it around and mouthing it. It's very hard so I'm not worried about her being able to chew off any little pieces at this point. This satisfies her for now and helps to keep her busy and reigns in some of her puppy energy. Recommend!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 9, 2026
N
Verified Purchase
Nunya B
Birmingham, US
★★★★★ 5
Strong
Size: Small, Color: Textured Ring
My French Bulldogs have really strong jaws and are aggressive chewers. These really are sturdy and last a good amount of time. I replace every couple of months and they are one of my dogs favorites and easy for them to hold onto.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 25, 2026
M
Verified Purchase
Marie Phillips
Dallas, US
★★★★★ 4
Durable Chew Toy That Actually Holds Up to Strong Jaws
Size: Large, Color: Bundle
This is a reliable option for a heavy chewer, especially for a large breed with a strong bite. The material feels tough and well-made, and it stands up well to consistent chewing without immediately breaking down like softer toys tend to do. It also gives a bit of dental benefit by helping reduce plaque and tartar buildup during play, which is a nice bonus since brushing isn’t always realistic. The textured surface keeps it interesting enough to hold attention for a while, and it doesn’t splinter or create a mess. Overall, it’s a solid, durable chew toy that works well for strong chewers who tend to destroy most standard toys quickly.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 6, 2026
J
Verified Purchase
Justina Stone
Belleville, US
★★★★★ 5
Ergonomic good, material so, so
Size: Large, Color: Wishbone
Nice ergonomic, but the plastic come off and dog chew it. I had rather have a stronger material adequate for bigger dogs.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 30, 2026

recommand products