Calcium AKG Longevity Powder - 100 grams

Extend a Healthy Lifespan with Calcium AKG Longevity

• Boost cellular energy*
• Optimize mitochondrial function*
• Promote healthy aging and longevity*
• Support bones, muscles, cognition, detoxification, and more*

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• Targets 7 Hallmarks of Aging: AKG activates key biological pathways that help slow age-related cellular decline and promote healthy aging.*
• Longevity-Focused Formula: AKG has been shown to extend lifespan in animal studies by up to 50% and reduce biological age markers in humans.*
•  Krebs Cycle Activation: AKG fuels cellular energy production by generating NADH, supporting ATP production for improved cellular health and repair.*
•  Downstream Benefits: AKG metabolizes into glutamate, supporting GABA production for a balanced mind and acting as a precursor to glutathione, the body’s master detoxifier and antioxidant. Additionally, it converts into glutamine, providing fuel for gastrointestinal cells.*

What Makes Ours Better?

• Doctor-Formulated Potency: Featuring a 1,000mg "longevity dose" of Calcium AKG. 
  
• Enhanced Stability: Calcium AKG is preferred over standard AKG due to its stability, bioavailability, and additional health benefits.*  
  
• Optimal Absorption: Calcium AKG crosses the cell membrane more efficiently than standard AKG.*
• Triple Lab Tested: Verified three times by independent third-party laboratories to ensure unmatched purity and potency.  We proudly publish test results.
• USA Manufacturing Excellence: Made in FDA-regulated, GMP-certified facilities in the USA for the highest quality and safety standards.
• 100-Day Risk-Free Guarantee: We stand behind our products. Not satisfied? Reach out to our Santa Barbara, CA office for a full refund within 100 days – no hassle, no questions.

Introducing ProHealth Calcium AKG Longevity, a revolutionary supplement that targets multiple pathways of aging. Alpha-ketoglutarate (AKG) is an essential molecule naturally produced by the body that plays a central role in energy metabolism and cellular repair. However, AKG levels decline sharply with age—dropping up to 10-fold between the ages of 40 and 80. Supplementation is necessary to maintain optimal levels as the compound is not found in food.^1*

Supplementing with Calcium AKG Longevity addresses this deficiency by supplying you with a bioavailable form of AKG, designed to cross the cell membrane and fuel critical metabolic processes. It supports ATP Production, helping to enhance mitochondrial function and promote efficient energy production through the Krebs cycle. It also helps maintain DNA integrity and regulate gene expression and DNA methylation, which are key factors involved in healthy aging.*

Additionally, AKG acts as a precursor to the compound glutathione, which has antioxidant effects and helps neutralize ammonia in the body, supporting a healthy detoxification process.*

In animal studies, AKG has been shown to help extend lifespan by 10% in mice, 23% in flies, and 50% in worms.¹ In human studies, AKG supplementation shows promising results for reducing biological age markers and improving overall vitality. This may be due to its effects on key pathways associated with aging, including rapamycin (mTOR) and AMP-activated protein kinase (AMPK).^3*

Extend a Healthy Lifespan with Calcium AKG Longevity*

Boosts Cellular Energy Production*
Calcium AKG supports cellular energy by fueling the Krebs cycle, which enhances ATP production and ensures that your cells have the energy needed for optimal function. Additionally, it plays a critical role in maintaining mitochondrial efficiency, helping to combat the natural decline in energy associated with aging.^{2, 4*}

Supports Longevity Pathways*
Calcium AKG regulates key longevity pathways, including mTOR and AMPK, to promote a healthy balance between cellular growth and repair. This regulation is essential for supporting the body’s natural processes that maintain cellular health over time. Calcium AKG also plays a role in DNA methylation, which helps regulate gene expression and supports healthy aging at the molecular level.^{2, 3, 1*}

Helps Maintain Bone Density*
As a valuable source of calcium, Calcium AKG provides 15% of the daily recommended value, supporting bone strength and density. This benefit is particularly important for aging individuals, as maintaining adequate calcium levels can help reduce the risk of age-related frailty and promote long-term physical resilience and strength.^6*

Supports Healthy Neurotransmitters*
Calcium AKG contributes to mental clarity and calm by supporting neurotransmitter balance. Specifically, it converts into glutamate, which is a key precursor for GABA, the brain’s calming neurotransmitter. By enhancing GABA production, Calcium AKG helps regulate the brain’s response to stress and supports a balanced mood and restful sleep.^2,3,5*

Encourages Detoxification and Antioxidant Production*
Calcium AKG aids the body’s natural detoxification processes by serving as a precursor to glutathione, the body’s master antioxidant. Glutathione plays a crucial role in combating oxidative stress and supporting overall cellular health.* Additionally, Calcium AKG helps neutralize excess ammonia in the body, which can support both brain and muscle function, promoting optimal performance and resilience.^{3, 5*}

Helps Maintain Strength*
Much of AKG is metabolized into glutamine and other essential amino acids that can aid in the maintenance of lean muscle mass. By potentially supporting bone health, muscle function, and cellular energy production, Ca-AKG may help maintain physical strength and vitality as you age, enabling you to stay active and engaged in life's adventures.^3,8*

For athletes, studies indicate that daily doses of 3 to 4 grams of AKG, administered 1–2 times per day, may improve endurance and anaerobic capacity. Supplementation for a period of 4 to 8 weeks appears to be effective, with administration typically in powder or capsule form. For immediate performance benefits, taking AKG before exercise is commonly recommended.^7*

Aids in Immune Function*
Glutamine also functions as fuel for gastrointestinal and immune cells, contributing to a healthy gastrointestinal lining and immune system. Supplementation may aid in overall immune defenses, as glutamine is an important fuel for lymphocytes and macrophages, types of white blood cells that can help fight against pathogens.^5,8*

Feel the Difference in Your Energy with Calcium AKG Longevity

Replenish what aging takes away with help from ProHealth’s Calcium AKG Longevity, which is specifically designed to restore cellular energy, enhance resilience, and promote long-term vitality. Whether you’re looking to stay active, maintain bone strength, or optimize your cellular health, this powerful supplement delivers results you can feel.*

Order now and join the thousands of people who trust ProHealth for their longevity journey!

Ingredients:

• Calcium: Essential mineral that supports strong bones and teeth, aids muscle function, and plays a key role in nerve transmission and cellular processes.*
• Alpha-Ketoglutarate (AKG): Key intermediate in the Krebs cycle, essential for cellular energy production and overall metabolic health.*

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

References:

¹ Naeini SH et al. Exp Gerontol. 2023;175:112154.
² Sandalova E et al. GeroScience. 2023;45(5):2897-2907. 
³ Gyanwali B et al. Trends Endocrinol Metab. 2022;33(2):136-146. 
⁴ Demidenko O et al. Aging. 2021;13(22):24485-24499.
⁵ Liu S et al. BioMed Res Int. 2018;2018:3408467. 
⁶ Trailokya A et al. Calcium and Calcium Salts. 
⁷ Xu M et al. Nutrients. 2024;16(22):3968. 
⁸ Wu N et al. Biomol Ther. 2016;24(1):1-8.