SKU: 87097093269

Hista Clear - DAO Enzyme (60 tablets)

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Description

Hista Clear - DAO Enzyme (60 tablets)NEW: Now in NEW packaging Conners Clinic Originals Hista Clear is a patented enzyme formula containing diamine oxidase (DAO) the main enzyme responsible for the degradation of ingested histamine. This enzyme has been clinically tested and found to break down food derived histamine in the digestive tract. Our bodies are complex, and there is usually more at play than we think. What most dont take into consideration when addressing histamine related

NEW: Now in NEW packaging

Conners Clinic Originals Hista Clear is a patented enzyme formula containing diamine oxidase (DAO) - the main enzyme responsible for the degradation of ingested histamine.  This enzyme has been clinically tested and found to break down food-derived histamine in the digestive tract.  

Our bodies are complex, and there is usually more at play than we think. What most don’t take into consideration when addressing histamine-related health issues is genetics. Whether you’re on a low histamine diet due to histamine intolerance, or simply trying to reduce high histamine foods for general health, you will benefit from understanding how your genes are related. Learn more about histamine and genetics here!

Our body has two distinct methods of clearing things that could bring it harm: our immune system kills living toxins (bacteria, virus, parasites…) and our detoxification pathways clear non-living toxins (chemicals, heavy metals, drugs…). We have one other system that sits somewhere in the middle between the immune and the detoxification systems that helps with both: the mast cells. Read more about Histamine’s Double-edge Sword in the Formation and Progression of Cancer.

 

Clinical Applications
  • Supports Healthy Degradation of Food-Derived Histamine*
  • Enhances the Presence of Diamine Oxidase in the Digestive Tract*
Description:


Hista Clear provides a concentrated source of diamine oxidase (DAO)—the main enzyme responsible for the degradation of ingested histamine. This formula delivers the clinically researched dose of DAO in an easy-to-swallow, gastro-resistant mini-tablet, which is essential for releasing DAO in the small intestine, where it breaks down food-derived histamine. HistDAO does not manage or address antibody-related or IgE-related food allergies.*

Discussion:

Histamine is a bioactive or “vasoactive” amine produced in the body in response to an injury or foreign substance. It has an array of physiological effects, including increasing blood supply to specific sites in the body. In addition, histamine is involved in the immune response, regulation of gastric acid, permeability of blood vessels, contraction of muscles, and the normal response to inflammation.[1] The highest concentrations of histamine in the body are found in the gastrointestinal tract, lungs, and skin, with lesser amounts in the brain and heart.*

Histamine is not only produced in the body but is also present in many fermented foods, such as sauerkraut, sausage, cheese, yogurt, and alcoholic beverages. Tuna, olives, spinach, eggplant, avocados, tomatoes, cherries, and citrus fruits are other histamine-containing foods. Despite their absence of histamine, some foods, such as berries, tea, and a variety of spices, stimulate the endogenous production of the amine due to their benzoate content. In addition, microbial fermentation can convert the histidine in high-protein foods to histamine so that the histamine content of food can increase over time.*[1]

Endogenous and exogenous histamine must be broken down in order to maintain homeostasis and histamine balance. The enzyme diamine oxidase (DAO) degrades histamine by converting it from 2-(4-imidazolyl)- ethylamine to the inactive metabolite imidazole acetaldehyde.[2] The active ingredient in HistaClear is porcine-derived diamine oxidase, and research suggests that DAO derived from porcine kidney appears to have identical action to DAO derived from porcine intestine.[3] In humans and other mammals, DAO is found in high concentrations in the gastrointestinal mucosa. Animal studies suggest that circulating DAO may be a marker for mucosal integrity and maturity.[4] Certain drugs may affect histamine balance in the body by promoting histamine release or inhibiting DAO.*[2]

Histamine tolerance may not be the same for everyone. Results of a double-blind, placebo-controlled crossover study suggest that tolerance to histamine can vary from individual to individual.[5] Total body histamine load must be considered when evaluating histamine tolerance, and a balance between histamine and DAO appears to be crucial to maintaining skin, rhinoconjunctival, and gastrointestinal health.[2,6] Genetic and environmental factors may interact to influence DAO expression. Ongoing research addresses the role that genetic variations may play in individual differences in DAO metabolism, and serum activity was significantly associated with seven single nucleotide variations within the DAO gene.[7,8] Histamine tolerance may be reflected in detailed questionnaires, food intake logs, trial with low-histamine diet, and measurement of DAO and histamine.*[9,10]

Histamine tolerance and its manifestation may vary from organ to organ as well. A study of 39 patients suggested that intake of DAO produced a statistically significant reduction in symptoms associated with exogenous histamine ingestion, although single symptoms were not found to be reproducible.*[11]

Ultimately, diminished serum DAO levels appear to be associated with changes in histamine degradation and serum histamine levels.[10] Although the mechanism of histamine degradation is uniform throughout the body, HistaClear only addresses excess exogenous histamine found in the folds, villi, and microvilli of the small intestine. HistaClear is not absorbed and therefore does not have systemic activity. A two-capsule dose of HistaClear contains 20 mg of vitamin C and 20,000 HDU (histamine degrading units) from diamine oxidase. HistaClear is NOT EFFECTIVE for symptoms of immune- related food allergies, such as peanuts, shellfish, etc.*

Read our article: Low Histamine Diet: The High Histamine Foods List

Genetic supplementation is complex and requires a deep understanding of the entire genetic picture.  Our Genetics Membership includes the kit, a full workup, review, report, summary, Dr. Conners’ personalized recommendations - and MORE.  Click HERE for details.

Video:


Directions:

Take 1-2 capsules no more than 15 minutes before the consumption of histamine-rich foods, or take as directed by your healthcare practitioner.

Cautions:

Consult your healthcare practitioner before use, especially if you are pregnant or nursing. Keep out of reach of children. Avoid if allergic to pork or any other ingredient. HistaClear is NOT EFFECTIVE for symptoms of immune- related food allergies, such as peanuts, shellfish, etc.


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SKU: 87097093269

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Katelyn
Whiting, US
★★★★★ 5
Order it! Its great
Style: Deep Moisturizing, Size: 1.76 Fl Oz (Pack of 1)
I love the texture! Its silky smooth and light on the skin, no weird smell, very moisturizing. Ive used one of the containers for most of my pregnancy to keep the skin on my belly and hips moisturized. I add a few drops of organic frankincense to a nickel-sized amount of this balm and mix it together in my hands before applying. I use a clean q-tip to scoop out the tallow balm as needed too to be sure the rest in the jar stays clean, rather than using my washed fingers, to reduce accidentally contaminating the rest of it somehow. My skin has stayed so healthy thanks to this product. It reduces the itchiness of my expanding skin from the baby growing in my belly, and i think its made a positive difference in preventing stretch marks by keeping my skin hydrated as i use it almost daily and after every shower. I just got my second jar in the mail to use for this last month of my pregnancy, and I will probably use it for my baby when hes born too. I also love that it comes in nice packaging, with a thank you note, very minimal plastic, and classy label. I dont think the jar is plastic either which i LOVE (pretty sure its glass container?) Thank you to the creators of this product. I kind of wish i could get it in a glass dispenser like lotion but i really dont care at the end of the day. Its amazing. You should try it.
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Reviewed in the United States on May 31, 2026
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Betrose95
Lowell, US
★★★★★ 5
Smells nice and light
Style: Deep Moisturizing, Size: 1.76 Fl Oz (Pack of 1)
Nice and creamy. Feels silky. Unfortunately, it does not help my knuckles very much. But I would buy it again because it is a good cream.
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Reviewed in the United States on May 15, 2026
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Wendy Martinez
Lowell, US
★★★★★ 5
Excelentt
Style: Deep Moisturizing, Size: 1.76 Fl Oz (Pack of 1), Style: Deep Moisturizing, Size: 1.76 Fl Oz (Pack of 1)
This product is really good, I researched it because it is the closest to human skin, and that was what it did help me repair my skin that was injured after an allergy of more than two months. I felt that I had lost the elasticity and shape of my skin, this fat stuck to me and made me feel safe again.
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Reviewed in the United States on May 24, 2026
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Laura Z.
Lowell, US
★★★★★ 4
Will repurchase
Style: Deep Moisturizing, Size: 1.76 Fl Oz (Pack of 1)
At 56 years old my skin is pretty dry but this was still a little to heavy for a face cream-- but usable in a pinch. What it is PERFECT for is for your hands before you go to sleep at night. You know you're going to touch your face and pillow during the night so heavily fragranced creams aren't good at all. This is thick enough to make your hands and cuticles feel great but gentle enough not to cause problems if transferred onto your face.
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Reviewed in the United States on June 1, 2026
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Elmira
Lowell, US
★★★★★ 5
Soft and Smooth!
Style: Deep Moisturizing, Size: 1.76 Fl Oz (Pack of 1)
This product feels fantastic when you put it on. A little goes a very long way so you get a lot for your money. It does work great after just lightly drying your face. There isn’t much of a smell, which I prefer. I have very sensitive skin and this is so soothing to use. I’m also in my late 40’s so the soft, plump and smooth look achieved after using this is so nice. If it makes your skin greasy at all you are using too much.
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Reviewed in the United States on April 28, 2026

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