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Description
EphB2 His Tag Protein, HumanProduct Specification Species Human Antigen EphB2 Synonyms CAPB, Cek5, Drt, DRTEphB2, EC 2. 7. 10, EC 2. 7. 10. 1, EK5, elk related tyrosine kinase, EPH receptor B2, eph tyrosine kinase 3, EphB2, EPH like kinase 5, ephrin type B receptor 2, EPHT3MGC87492, EPTH3, Erk, ERKHek5, Hek5, Nuk, PCBC, protein tyrosine kinase HEK5, Qek2, Renal carcinoma antigen NY REN 47, Sek3, Tyro5, Tyrosine protein kinase receptor EPH 3, Tyrosine protein kinase TYRO5
Product Specification
| Species | Human |
| Antigen | EphB2 |
| Synonyms | CAPB, Cek5, Drt, DRTEphB2, EC 2.7.10, EC 2.7.10.1, EK5, elk-related tyrosine kinase, EPH receptor B2, eph tyrosine kinase 3, EphB2, EPH-like kinase 5, ephrin type-B receptor 2, EPHT3MGC87492, EPTH3, Erk, ERKHek5, Hek5, Nuk, PCBC, protein-tyrosine kinase HEK5, Qek2, Renal carcinoma antigen NY-REN-47, Sek3, Tyro5, Tyrosine-protein kinase receptor EPH-3, Tyrosine-protein kinase TYRO5 |
| Accession | P29323 |
| Amino Acid Sequence | Val19-Leu543, with C-terminal 10*His VEETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEMKFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQDYGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCRGCPSGTFKANQGDEACTHCPINSRTTSEGATNCVCRNGYYRADLDPLDMPCTTIPSAPQAVISSVNETSLMLEWTPPRDSGGREDLVYNIICKSCGSGRGACTRCGDNVQYAPRQLGLTEPRIYISDLLAHTQYTFEIQAVNGVTDQSPFSPQFASVNITTNQAAPSAVSIMHQVSRTVDSITLSWSQPDQPNGVILDYELQYYEKELSEYNATAIKSPTNTVTVQGLKAGAIYVFQVRARTVAGYGRYSGKMYFQTMTEAEYQTSIQEKLPLGGGSGGGSHHHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | 70-80kDa |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1. Nonsense-mediated decay microarray analysis identifies mutations of EPHB2 in human prostate cancer. Huusko P., Ponciano-Jackson D., Wolf M., Kiefer J.A., Azorsa D.O., Tuzmen S., Weaver D., Robbins C., Moses T., Mousses S. 2. A mutation of the human EPHB2 gene leads to a major platelet functional defect. Berrou E., Soukaseum C., Favier R., Adam F., Elaib Z., Kauskot A., Bordet J.C., Ballerini P., Loyau S., Bryckaert M. |
Background
Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. In addition to axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of development including angiogenesis, palate development and in inner ear development through regulation of endolymph production. Forward and reverse signaling through the EFNB2/EPHB2 complex regulate movement and adhesion of cells that tubularize the urethra and septate the cloaca. May function as a tumor suppressor. May be involved in the regulation of platelet activation and blood coagulation.
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