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Description
Snail Recombinant Rabbit mAb (S-3257)Product Specification Host Rabbit Antigen Snail Synonyms Zinc finger protein SNAI1; Protein snail homolog 1 (Protein sna); SNAH; SNAI1 Location Cytoplasm, Nucleus Accession O95863 Clone Number S 3257 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu, Ms, Mk Positive Sample HCT 116, HeLa , A549, SW480, NIH 3T3, COS 7 Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer
Product Specification
| Host | Rabbit |
| Antigen | Snail |
| Synonyms | Zinc finger protein SNAI1; Protein snail homolog 1 (Protein sna); SNAH; SNAI1 |
| Location | Cytoplasm, Nucleus |
| Accession | O95863 |
| Clone Number | S-3257 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu, Ms, Mk |
| Positive Sample | HCT 116, HeLa , A549, SW480, NIH/3T3, COS-7 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Mk |
Background
Snail protein, a zinc-finger transcription factor encoded by the SNAI1 gene, is a master regulator of epithelial-to-mesenchymal transition (EMT) that represses E-cadherin and other epithelial genes, thereby promoting cell motility, invasion, and stemness, and its overexpression in diverse carcinomas is strongly linked to metastasis, chemoresistance, and poor prognosis through activation of oncogenic signaling pathways such as TGF-β, Wnt/β-catenin, and NF-κB, while its activity is modulated by post-translational modifications, including phosphorylation, ubiquitination, and acetylation, making it both a biomarker and a therapeutic target in cancer biology.
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