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Description
GM-CSFR α His Tag Protein, HumanProduct Specification Species Human Synonyms GMR, CD116, CSF2R, SMDP4, CSF2RAX, CSF2RAY, CSF2RX, SMDP4 Accession P15509 Amino Acid Sequence Glu23 Gly320, with C 8*His Expression System HEK293 Molecular Weight 55 70kDa Purity >95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4 Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after
Product Specification
| Species | Human |
| Synonyms | GMR, CD116, CSF2R, SMDP4, CSF2RAX, CSF2RAY, CSF2RX, SMDP4 |
| Accession | P15509 |
| Amino Acid Sequence | Glu23-Gly320, with C-8*His |
| Expression System | HEK293 |
| Molecular Weight | 55-70kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference |
1、Prevost J M. et al. (2002) Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) and Inflammatory Stimuli Up-Regulate Secretion of the Soluble GM-CSF Receptor in Human Monocytes: Evidence for Ectodomain Shedding of the Cell Surface GM-CSF Receptor α Subunit. J Immunol. 169(10): 5679-5688. 2、Cao Y. et al. (2007) Angiogenesis modulates adipogenesis and obesity. J Clin Invest. 117(9): 2362-2368. 3、Fleetwood A J. et al. (2005) Functions of Granulocyte-Macrophage Colony-Stimulating Factor. Crit Rev Immunol. 25(5): 405-428. |
Background
GM-CSF receptor alpha is a member of the cytokine family of receptors. GM-CSF receptor alpha is found in the pseudoautosomal region of the X and Y chromosomes. GM-CSF receptor alpha has different isoform, with some of the isoforms being membrane-bound and others being soluble. Soluble GM-CSF receptor alpha subunit is a soluble isoform of the GMR alpha that is believed to arise exclusively through alternative splicing of the GMR alpha gene product. The sGMR alpha mRNA is expressed in a variety of tissues, but it is not clear which cells are capable of secreting the protein. Hereditary pulmonary alveolar proteinosis (hPAP) is a rare disorder of pulmonary surfactant accumulation and hypoxemic respiratory failure caused by mutations in GM-CSF receptor alpha, which results in reduced GM-CSF-dependent pulmonary surfactant clearance by alveolar macrophages. While no pharmacologic therapy currently exists for hPAP, it was recently demonstrated that endotracheal instillation of wild-type or gene-corrected mononuclear phagocytes results in a significant and durable therapeutic efficacy in a validated murine model of hPAP.
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Exchange/Return Notes
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4.3 ★★★★★
Based on 17 reviews
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Product Reviews
★★★★★ 5
Haru LOVES this toy!
I recently purchased the Amazon Basics Hide and Seek Squeaky Dog Plush Toy, Rabbit and Carrot 5 Pack, and it has been an absolute hit with my dog Haru! This set has quickly become his favorite playtime activity, and it's easy to see why.
From the moment I introduced Haru to the plush toys, he was hooked! The rabbit and carrot design is not only adorable but also adds an element of excitement and curiosity for him. The toys' quality is impressive, with sturdy stitching that has held up well to Haru's enthusiastic play style.
The "hide and seek" aspect of the toys is brilliant. Each plush toy contains squeakers, which immediately captured Haru's attention. He thoroughly enjoys searching for the source of the squeaky sound and then triumphantly "catching" the rabbit or carrot. It's like a mini-game that keeps him mentally stimulated and entertained.
One of the best things about this 5-pack set is the variety it offers. Haru never gets bored because he can alternate between the different plush toys, and each one presents a new challenge for him. Whether he's "hunting" the rabbit or "nibbling" on the carrot, his excitement is contagious!
Furthermore, I appreciate how these toys keep Haru engaged for a good amount of time. As a busy dog owner, it's essential to have toys that can entertain him while I'm occupied with other tasks. The Hide and Seek Squeaky Dog Plush Toy accomplishes this perfectly, giving me some peace of mind knowing Haru is happily occupied.
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Reviewed in the United States on July 21, 2023
★★★★★ 5
Great toy
Great size for a medium to large dog and a good value overall. The carrot foliage is made of felt and can tear easily, but the carrot body and bunnies have typical toy durability. The bunnies include squeakers that are softer and not high-pitched. The holes are sized well—small enough that the bunnies don’t fall out on their own. Even with only a few stuffed inside, they stay put until your dog pulls them out.
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Reviewed in the United States on November 30, 2025
★★★★★ 5
I was shocked by how much my daughter's puppy enjoyed this toy!
I've bought two of these — one for my grand puppy to use when she's at my house, and another for her to keep at her house. I was shocked that she actually seems to enjoy playing with this toy! She hunts out all the bunnies and then brings the carrot to me to refill. I refill it, and then she takes the refilled carrot back to her spot and hunts them all out again. If I can't find one of the bunnies (because it's gotten stuck in the couch cushion, for example), I ask her "where's the bunny?" and she helps me find it! This dog is a ferocious chewer but she doesn't chew these toys! It's like she instinctively knows they are for hunting, not chewing. As a result, they have lasted a long time and provide hours of quality fun. Great value!
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Reviewed in the United States on April 7, 2026
★★★★★ 5
My Iggies LOVE this toy. Buy it!!!!!
As a new dog mom to Italian greyhounds, I wasn’t sure if they’d like this, but it is their favorite toy!!!! They LOVE playing with the rabbits, chewing on them, squishing them, flinging them and chasing them. My one iggy likes to chew on the carrot and stick her nose in it when it’s empty. I find the rabbits around the house. So cute and seems to be well made. Definitely worth the cost.
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Reviewed in the United States on March 18, 2026
★★★★★ 5
Very cute and well loved dog toy.
I have two maltese rescue dogs. One if still a puppy and the other is almost 5 years old. The youngest one is a chewer and goes through toys removing whatever she can as soon as she can. This is a VERY cute toy and comes with the 4 cute bunnies inside. My older dog loves to take the bunnies and cuddle them in her bed. So far the chewer has not been able to take them apart and for that I am very pleased. Very well made, stiched well. I was reluctant at first to purchase because of price, but I believe this is good value for your money.
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Reviewed in the United States on February 1, 2026
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