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Description
SAGE1 Recombinant Rabbit mAb (SDT-317-60)Product Specification Host Rabbit Antigen SAGE1 Synonyms Sarcoma antigen 1, Cancer testis antigen 14 (CT14), SAGE Immunogen Recombinant Protein Location Nucleus Accession Q9NXZ1 Clone Number SDT 317 60 Antibody Type Recombinant mAb Application IHC P Reactivity Hu Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05%BSA, 0. 03% Proclin 300 Stability & Storage 12
Product Specification
| Host | Rabbit |
| Antigen | SAGE1 |
| Synonyms | Sarcoma antigen 1, Cancer/testis antigen 14 (CT14), SAGE |
| Immunogen | Recombinant Protein |
| Location | Nucleus |
| Accession | Q9NXZ1 |
| Clone Number | SDT-317-60 |
| Antibody Type | Recombinant mAb |
| Application | IHC-P |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| IHC | 1:500 | null |
Background
Cancer/testis (CT) antigens including MAGEA, NY-ESO-1, GAGE, CT7, CT10, CT45, SAGE1, and NXF2 are protein antigens that are normally expressed in the germ cells of adult testis and developing fetal testis and ovary, but not in any other adult tissues. Examination of various types of human cancer showed CT gene activation and protein expression in a proportion of human cancers in a lineage-unrelated fashion. Due to this restricted pattern of expression, CT antigens are often recognized by the immune system of cancer patients, and this spontaneous immunogenicity raises the possibility of their use as therapeutic cancer vaccine targets.
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