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Description
PPIA Recombinant Rabbit mAb (S-2406-28)Product Specification Host Rabbit Antigen PPIA Synonyms Peptidyl prolyl cis trans isomerase A; PPIase A; Cyclophilin A; Cyclosporin A binding protein; Rotamase A; CYPA Immunogen Synthetic Peptide Location Secreted, Cytoplasm, Nucleus Accession P62937 Clone Number S 2406 28 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC, ICFCM Reactivity Hu, Ms, Rt Positive Sample K562, HeLa, Jurkat, HepG2, A431, NIH 3T3, EL4, C2C12, mouse brain,
Product Specification
| Host | Rabbit |
| Antigen | PPIA |
| Synonyms | Peptidyl-prolyl cis-trans isomerase A; PPIase A; Cyclophilin A; Cyclosporin A-binding protein; Rotamase A; CYPA |
| Immunogen | Synthetic Peptide |
| Location | Secreted, Cytoplasm, Nucleus |
| Accession | P62937 |
| Clone Number | S-2406-28 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC, ICFCM |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | K562, HeLa, Jurkat, HepG2, A431, NIH/3T3, EL4, C2C12, mouse brain, mouse heart, mouse kidney, mouse spleen |
| Predicted Reactivity | Ct, Bv, CtTa |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:5000 | Hu, Ms |
| IHC-P | 1:250 | Hu, Ms, Rt |
| ICC | 1:500 | Hu, Ms |
| ICFCM | 1:500 | Hu, Ms |
Background
PPIA (peptidyl-prolyl cis-trans isomerase A), also called cyclophilin A, is a 165-amino-acid, ubiquitously expressed cytoplasmic enzyme that catalyzes the cis-trans isomerization of prolyl peptide bonds and thus accelerates protein folding; beyond this chaperone-like role, it is a critical virulence factor for HIV-1, because the viral capsid recruits PPIA to shield itself from host restriction factors, while extracellular PPIA, secreted under inflammatory or oxidative stress, acts as a chemoattractant for monocytes and T cells via CD147/EMMPRIN, thereby amplifying inflammatory cascades in cardiovascular disease, viral infection, and cancer.
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