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Description
c-Jun Recombinant Rabbit mAb (S-494-457)Product Specification Host Rabbit Antigen c Jun Synonyms Transcription factor Jun; Activator protein 1 (AP1); Proto oncogene c Jun; Transcription factor AP 1 subunit Jun; V jun avian sarcoma virus 17 oncogene homolog; p39; JUN Immunogen Synthetic Peptide Location Nucleus Accession P05412 Clone Number S 494 457 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu, Ms Positive Sample PC 3, MDA MB 231 Purification Protein A
Product Specification
| Host | Rabbit |
| Antigen | c-Jun |
| Synonyms | Transcription factor Jun; Activator protein 1 (AP1); Proto-oncogene c-Jun; Transcription factor AP-1 subunit Jun; V-jun avian sarcoma virus 17 oncogene homolog; p39; JUN |
| Immunogen | Synthetic Peptide |
| Location | Nucleus |
| Accession | P05412 |
| Clone Number | S-494-457 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu, Ms |
| Positive Sample | PC-3, MDA-MB-231 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms |
Background
c-Jun is a key component of the transcription factor complex AP-1 (Activator Protein 1) and is one of the most transcriptionally active members of this complex. It is involved in a wide range of cellular processes, including cell proliferation, differentiation, apoptosis, and the regulation of inflammatory responses. c-Jun can be activated by various stimuli, such as growth factors, cytokines, and stress signals, which lead to its phosphorylation and subsequent regulation of gene expression. In cancer biology, c-Jun has been implicated in tumor initiation and progression, particularly in liver cancer, where it can promote cell survival and inhibit apoptosis through interactions with other signaling pathways. Additionally, c-Jun plays a role in immune cell function and has been studied for its impact on T-cell exhaustion and immune response regulation. Its diverse functions highlight its importance as a regulatory hub in cellular signaling and gene expression networks.
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