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Description
TOMM20 Recombinant Rabbit mAb (SDT-2553-11)Product Specification Host Rabbit Antigen TOMM20 Synonyms Mitochondrial import receptor subunit TOM20 homolog; Mitochondrial 20 kDa outer membrane protein; Outer mitochondrial membrane receptor Tom20; KIAA0016 Immunogen Recombinant Protein Location Mitochondrion Accession Q15388 Clone Number SDT 2553 11 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms, Rt Positive Sample HepG2, HeLa, SH SY5Y, NIH 3T3, PC 12, mouse
Product Specification
| Host | Rabbit |
| Antigen | TOMM20 |
| Synonyms | Mitochondrial import receptor subunit TOM20 homolog; Mitochondrial 20 kDa outer membrane protein; Outer mitochondrial membrane receptor Tom20; KIAA0016 |
| Immunogen | Recombinant Protein |
| Location | Mitochondrion |
| Accession | Q15388 |
| Clone Number | SDT-2553-11 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | HepG2, HeLa, SH-SY5Y, NIH/3T3, PC-12, mouse kidney, mouse heart, mouse skeletal muscle, PC-12, rat kidney, rat heart, rat skeletal muscle |
| Predicted Reactivity | Bv |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:5000 | Hu, Ms, Rt |
| IHC-P | 1:1000 | Hu, Ms, Rt |
| ICC | 1:500 | Hu, Ms, Rt |
Background
TOMM20 (Translocase of Outer Mitochondrial Membrane 20) is a ~20 kDa receptor subunit of the TOM complex embedded in the outer mitochondrial membrane; together with TOMM22 it forms the initial binding site that recognizes N-terminal matrix-targeting sequences on cytosol-synthesized pre-proteins and threads them through the TOMM40 channel into mitochondria, thereby governing mitochondrial biogenesis and bioenergetics, while also moonlighting as a mitophagy adaptor via PINK1, a regulator of apoptosis through BCL2/BAX, and a chaperone-like stabilizer of the androgen receptor in prostate cancer, making it a widely used marker for mitochondrial mass and a potential biomarker for diseases such as Parkinson’s and cancer .
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