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Description
HAT1 Recombinant Rabbit mAb (S-2429-14)Product Specification Host Rabbit Antigen HAT1 Synonyms Histone acetyltransferase type B catalytic subunit; Histone acetyltransferase 1; KAT1 Immunogen Recombinant Protein Location Cytoplasm, Nucleus, Mitochondrion Accession O14929 Clone Number S 2429 14 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC, IF Reactivity Hu, Ms, Rt, Mk Positive Sample HeLa, Jurkat, MCF7, NIH 3T3, RAW264. 7, mouse colon, C6, PC 12, rat colon, COS 7
Product Specification
| Host | Rabbit |
| Antigen | HAT1 |
| Synonyms | Histone acetyltransferase type B catalytic subunit; Histone acetyltransferase 1; KAT1 |
| Immunogen | Recombinant Protein |
| Location | Cytoplasm, Nucleus, Mitochondrion |
| Accession | O14929 |
| Clone Number | S-2429-14 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC, IF |
| Reactivity | Hu, Ms, Rt, Mk |
| Positive Sample | HeLa, Jurkat, MCF7, NIH/3T3, RAW264.7, mouse colon, C6, PC-12, rat colon, COS-7 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:5000 | Hu, Ms, Rt, Mk |
| IHC-P | 1:1000 | Hu, Ms |
| ICC | 1:500 | Hu, Ms |
| IF | 1:500 | Ms |
Background
HAT1 (Histone Acetyltransferase 1) is an evolutionarily conserved type-B histone acetyltransferase that catalyzes the acetylation of newly synthesized histone H4 on lysines 5 and 12, and to a lesser extent H3, a modification critical for chromatin assembly and epigenetic regulation; residing mainly in the cytoplasm and nucleus, it forms a multisubunit complex with histone chaperones such as RbAp46 and NASP to escort acetylated histones to replication forks, is implicated in DNA repair, transcriptional silencing, and cell-cycle progression, and its dysregulation has been linked to cancers, viral latency, and neurodegeneration.
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