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Description
Rat Anti-Human CD115 Antibody (S-R722)Product Specification Host Rat Antigen CD115 Synonyms Macrophage colony stimulating factor 1 receptor; CSF 1 receptor (CSF 1 R; CSF 1R; M CSF R); Proto oncogene c Fms; FMS; CSF1R Location Cell membrane Accession P07333 Clone Number S R722 Antibody Type Rat mAb Isotype IgG1,k Application FCM Reactivity Hu Positive Sample human peripheral blood leukocyte Purification Protein G Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid
Product Specification
| Host | Rat |
| Antigen | CD115 |
| Synonyms | Macrophage colony-stimulating factor 1 receptor; CSF-1 receptor (CSF-1-R; CSF-1R; M-CSF-R); Proto-oncogene c-Fms; FMS; CSF1R |
| Location | Cell membrane |
| Accession | P07333 |
| Clone Number | S-R722 |
| Antibody Type | Rat mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | human peripheral blood leukocyte |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1:200 | Hu |
Background
CD115, also known as Colony-Stimulating Factor 1 Receptor (CSF1R) or M-CSF receptor (M-CSFR), is a 972-amino-acid cell-surface glycoprotein encoded by the CSF1R gene (c-FMS proto-oncogene) that belongs to the type III receptor tyrosine kinase family; it serves as a receptor for the cytokines CSF-1 and IL-34, and is highly expressed on monocyte-lineage cells and osteoclasts, mediating their survival, proliferation, differentiation, and motility through ligand-induced oligomerization and transphosphorylation, with mutations linked to myeloid malignancies and increased expression observed in Alzheimer’s disease microglia and breast carcinogenesis .
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