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Description
Anti-Gulgafafusp alfa Monoclonal Antibody (Glutazumab)Product Specification Host Human Synonyms Gulgafafusp alfa, Glutazumab Concentration 2mg mL Expression System HEK293 Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, PH7. 4 Stability & Storage 2 to 8 C for 2 weeks under sterile conditions; 20 C for 3 months under sterile conditions; 80 C for 24 months under sterile conditions. Please avoid repeated freeze thaw cycles. Reference 1. Drucker DJ. GLP 1 based therapies for diabetes,
Product Specification
| Host | Human |
| Synonyms | Gulgafafusp alfa, Glutazumab |
| Concentration | 2mg/mL |
| Expression System | HEK293 |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, PH7.4 |
| Stability & Storage | 2 to 8 °C for 2 weeks under sterile conditions; |
| Reference | 1. Drucker DJ. GLP-1-based therapies for diabetes, obesity and beyond. Nat Rev Drug Discov. 2025 Aug;24(8):631-650. doi: 10.1038/s41573-025-01183-8. Epub 2025 Apr 25. Erratum in: Nat Rev Drug Discov. 2025 Jul;24(7):570. |
Background
Gulgafafusp alfa is a humanized IgG2κ monoclonal antibody fusion protein targeting the glucagon-like peptide-1 receptor (GLP-1R) for the treatment of type 2 diabetes mellitus and obesity. This protein is engineered through genetic fusion of a GLP-1(7-35) agonist fragment to the Fc region of an anti-GLP-1R antibody, forming a unique "antibody-ligand" bifunctional structure: the antibody moiety specifically binds to GLP-1R, while the GLP-1 fragment activates downstream cAMP signaling pathways. Through synergistic dual receptor binding sites, this design significantly enhances binding affinity and prolongs half-life. As a long-acting GLP-1R agonist, Gulgafafusp alfa promotes glucose-dependent insulin secretion, suppresses glucagon release, delays gastric emptying, and increases satiety, thereby achieving sustained glycemic control and weight reduction effects.
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