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Description
CDK6 Recombinant Rabbit mAb (SDT-R047)Product Specification Host Rabbit Antigen CDK6 Synonyms Cyclin dependent kinase 6, CDKN6 Immunogen N A Location Cytoplasm, Nucleus Accession Q00534 Clone Number SDT R047 Antibody Type Rabbit mAb Application WB, IP Reactivity Hu Purification Protein A Concentration 0. 5 mg ml Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05%BSA, 0. 03% Proclin 300 Stability & Storage 12 months from date of receipt reconstitution, 20 C as supplied
Product Specification
| Host | Rabbit |
| Antigen | CDK6 |
| Synonyms | Cyclin-dependent kinase 6, CDKN6 |
| Immunogen | N/A |
| Location | Cytoplasm, Nucleus |
| Accession | Q00534 |
| Clone Number | SDT-R047 |
| Antibody Type | Rabbit mAb |
| Application | WB, IP |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | null |
| IP | 1:25 | null |
Background
CDK6 is a key regulator during the G1/S cell cycle transition. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and regulates negatively cell differentiation, but is required for the proliferation of specific cell types. Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans.
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